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http://dx.doi.org/10.1136/bmjhci-2021-100335 | DOI Listing |
Signal Transduct Target Ther
January 2025
Breast Center, The Second Hospital of Shandong University, Jinan, China.
The potential benefits of pyrotinib for patients with trastuzumab-insensitive, HER2-positive early-stage breast cancer remain unclear. This prospective, multicentre, response-adapted study evaluated the efficacy and safety of adding pyrotinib to the neoadjuvant treatment of HER2-positive breast cancer patients with a poor response to initial docetaxel plus carboplatin and trastuzumab (TCbH). Early response was assessed using magnetic resonance imaging (MRI) after two cycles of treatment.
View Article and Find Full Text PDFACS Sens
January 2025
Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
The simultaneous detection of electroencephalography (EEG) signals and neurotransmitter levels plays an important role as biomarkers for the assessment and monitoring of emotions and cognition. This paper describes the development of boron and nitrogen codoped graphene-diamond (BNGrD) microelectrodes with a diameter of only 200 μm for sensing EEG signals and dopamine (DA) levels, which have been developed for the first time. The optimized BNGrD microelectrode responded sensitively to both EEG and DA signals, with a signal-to-noise ratio of 9 dB for spontaneous EEG signals and a limit of detection as low as 124 nM for DA.
View Article and Find Full Text PDFJ Med Internet Res
January 2025
Research Centre Jülich, Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Jülich, Germany.
Background: Traditional in-clinic methods of collecting self-reported information are costly, time-consuming, subjective, and often limited in the quality and quantity of observation. However, smartphone-based ecological momentary assessments (EMAs) provide complementary information to in-clinic visits by collecting real-time, frequent, and longitudinal data that are ecologically valid. While these methods are promising, they are often prone to various technical obstacles.
View Article and Find Full Text PDFJ Proteome Res
January 2025
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
Extracellular vesicles (EVs) are emerging as crucial biomarkers in cancer diagnostics and therapeutics with their heterogeneity presenting both challenges and opportunities in prostate cancer research. However, existing methods for isolating and characterizing EV subtypes have been limited by inefficient separation and inadequate proteomic analysis. Here we show an optimized centrifugal microfluidic device, Exodisc, that efficiently isolates large quantities of EV subtypes from particle-enriched medium, enabling comprehensive proteomic analysis of small (EV-S, 20-200 nm) and large (EV-L, >200 nm) EVs.
View Article and Find Full Text PDFDigit Biomark
December 2024
VivoSense, Inc., Newport Coast, CA, USA.
Introduction: Wrist-worn accelerometers can capture stepping behavior passively, continuously, and remotely. Methods utilizing peak detection, threshold crossing, and frequency analysis have been used to detect steps from wrist-worn accelerometer data, but it remains unclear how different approaches perform across a range of walking speeds and free-living activities. In this study, we evaluated the performance of four open-source methods for deriving step counts from wrist-worn accelerometry data, when applied to data from a range of structured locomotion and free-living activities.
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