AI Article Synopsis
- Liver transplantation is a key treatment for severe liver disease in kids, with living donor liver transplantation (LDLT) being a common option involving the left lateral segment (LLS) of the liver.
- The study examined 50 patients to find a reliable formula for estimating LLS volume (LLSV) using CT scans, but ultimately found that traditional demographic factors did not effectively predict LLSV.
- The conclusion suggests that donor candidates should be evaluated on an individual basis without excluding them due to their size, as LLSV was difficult to accurately predict.
Article Abstract
Background: Liver transplantation is definitive therapy for end stage liver disease in pediatric patients. Living donor liver transplantation (LDLT) with the left lateral segment (LLS) is often a feasible option. However, the size of LLS is an important factor in donor suitability - particularly when the recipient weighs less than 10 kg. In the present study, we sought to define a formula for estimating left lateral segment volume (LLSV) in potential LLS donors.
Methods: We obtained demographic and anthropometric measurements on 50 patients with Computed Tomography (CT) scans to determine whole liver volume (WLV), right liver volume (RLV), and LLSV. We performed univariable and multivariable linear regression with backwards stepwise variable selection (p < 0.10) to determine final models.
Results: Our study found that previously reported anthropometric and demographics variables correlated with volume were significantly associated with WLV and RLV. On univariable analysis, no demographic or anthropometric measures were correlated with LLSV. On multivariable analysis, LLSV was poorly predicted by the final model (R2 = 0.10, Coefficient of Variation [CV] = 42.2) relative to WLV (R2 = 0.33, CV = 18.8) and RLV (R2 = 0.41, CV = 15.8).
Conclusion: Potential LLS living donors should not be excluded based on anthropometric data: all potential donors should be evaluated regardless of their size.
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| http://dx.doi.org/10.1016/j.hpb.2021.04.018 | DOI Listing |
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