AI Article Synopsis
- Polyhydroxybutyrate (PHB) is a versatile carbon polymer produced by various organisms, with this review focusing on its metabolism, structure, and roles, particularly in cyanobacteria.
- While the specific function of PHB in cyanobacteria is not fully understood, these microorganisms have the potential to convert CO2 into bioplastic using solar energy.
- Recent studies on the model organism Synechocystis have uncovered complex regulation of PHB storage, leading to the development of a highly efficient cyanobacterial strain for PHB production.
Article Abstract
Polyhydroxybutyrate (PHB) is a carbon polymer with diverse functions, varying greatly on the organism producing it. This microreview describes the current knowledge about PHB metabolism, structure, and different physiological roles with a special focus on cyanobacteria. Despite the physiological function of PHB in the cyanobacterial phylum still being unknown, these organisms provide the unique opportunity to directly convert atmospheric CO2 into bioplastic using a solar-based process. Recent research on PHB metabolism in the cyanobacterial model organism Synechocystis revealed a sophisticated control of PHB granule formation. Novel insights about the metabolic background of PHB synthesis resulted in the engineering of the first cyanobacterial superproducer strain.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000515617 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The prohibitin ligand IN44 decreases Porphyromonas gingivalis mediated inflammation.
BMC Oral Health
December 2024
INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, CRBS, 1 Rue Eugène Boeckel, Strasbourg, 67084, France.
Background: Periodontitis is an inflammatory disease causing destruction of periodontal tissues. Controlling inflammation is crucial for periodontitis treatment. Prohibitins (PHBs) are emerging targets in the treatment of inflammatory diseases.
View Article and Find Full Text PDFEngineering xylose utilization in Cupriavidus necator for enhanced poly(3-hydroxybutyrate) production from mixed sugars.
Bioresour Technol
December 2024
Clean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Division of Energy and Environment Technology, KIST School, University of Science and Technology, Seoul 02792, Republic of Korea. Electronic address:
Lignocellulosic biomass is a promising renewable feedstock for biodegradable plastics like polyhydroxyalkanoates (PHAs). Cupriavidus necator, a versatile microbial host that synthesizes poly(3-hydroxybutyrate) (PHB), the most abundant type of PHA, has been studied to expand its carbon source utilization. Since C.
View Article and Find Full Text PDFProhibitin 1 tethers lipid membranes and regulates OPA1-mediated membrane fusion.
J Biol Chem
December 2024
Department of Chemistry, Faculty of Science, Fukuoka University, Fukuoka 814-0180, Japan. Electronic address:
Prohibitins (PHBs) are ubiquitously expressed proteins in the mitochondrial inner membrane (MIM) that provide membrane scaffolds for both mitochondrial proteins and phospholipids. Eukaryotic PHB complexes contain two highly homologous PHB subunits, PHB1 and PHB2, which are involved in various cellular processes, including metabolic control through the regulation of mitochondrial dynamics and integrity. Their mechanistic actions at the molecular level, however, particularly those of PHB1, remain poorly understood.
View Article and Find Full Text PDFPolyhydroxybutyrate Synthesis by the Halophilic Bacterium, Halomonas boliviensis, in Oil Palm Empty Fruit Bunch Hydrolysate.
Biopolymers
January 2025
Grupo de Bioprocesos, Facultad de Ingeniería Química, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Article Synopsis
- Polyhydroxyalkanoates (PHAs) are promising biodegradable plastics but are held back by high production costs.
- This study explored using Halomonas boliviensis to produce polyhydroxybutyrate (PHB) from oil palm empty fruit bunch (OPEFB) in high-salinity environments.
- Results showed H. boliviensis effectively synthesized PHB from various substrates, with the highest yield from glucose, indicating OPEFB could serve as a cost-effective and sustainable alternative for PHB production.
Antibiotics-Free Steady Bioproduction of Valuable Chemicals from Organic Wastes by Engineered through Targeted Gene Integration.
ACS Synth Biol
December 2024
CAS Key Laboratory of Urban Pollutant Conversion, Department of Environmental Science and Engineering, University of Science & Technology of China, Hefei 230026, China.
Bioproduction of chemicals by using engineered bacteria is promising for a circular economy but challenged the instability of the introduced plasmid by conventional methods. Here, we developed a two-plasmid INTEGRET system to reliably integrate the targeted gene into the genome, making it a powerful strain for efficient and steady bioproduction without requiring antibiotic addition. The INTEGRET system allows for gene insertion at over 75% inserting efficiency and flexibly controllable gene dosages.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!