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Psychosis is a hallmark of schizophrenia. It typically emerges in late adolescence and is associated with dopamine abnormalities and aberrant salience. Most genes associated with schizophrenia risk involve ubiquitous targets that may not explain delayed emergence of dopaminergic disruptions.
View Article and Find Full Text PDFIntergenerational neurotoxicity of polystyrene nanoplastics in offspring mice is mediated by dysfunctional microbe-gut-brain axis.
Environ Int
October 2024
School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address:
Nanoplastics (NPs) are ubiquitous in daily life, posing potential risks to the environment and human. While their negative effects on parental organisms have been extensively studied, intergenerational effects are still in the early stages of investigation. Here, we aimed to investigate the impact of maternal exposure to an environmentally relevant level of polystyrene NPs (PSNPs, 100 nm) during gestation and lactation (∼32 days, 50 μg/mouse/day) on neurotoxicity mediated by the microbe-gut-brain axis in offspring mice.
View Article and Find Full Text PDFIndependent operations of appetitive and aversive conditioning systems lead to simultaneous production of conflicting memories in an insect.
Proc Biol Sci
September 2024
Research Institute for Electric Science, Hokkaido University, Sapporo 060-0812, Japan.
Pavlovian conditioning is a ubiquitous form of associative learning that enables animals to remember appetitive and aversive experiences. Animals possess appetitive and aversive conditioning systems that memorize and retrieve appetitive and aversive experiences. Here, we addressed a question of whether integration of competing appetitive and aversive information takes place during the encoding of the experience or during memory retrieval.
View Article and Find Full Text PDFMeasuring G protein activation by spectrally resolved imaging fluorescence fluctuation spectroscopy.
Biophys J
August 2024
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri. Electronic address:
The activation of heterotrimeric G proteins through G-protein-coupled receptors (GPCRs) is a ubiquitous signaling mechanism in eukaryotic biology. The three principal molecular components of this cascade are the GPCR, Gα subunit, and Gβγ subunit. Measurement of interactions between these components and their downstream effectors in live cells is paramount to understanding how cells fine-tune their physiology in response to many external stimuli.
View Article and Find Full Text PDFWhen microscopy and electrophysiology meet connectomics-Steve Massey's contribution to unraveling the structure and function of the rod/cone gap junction.
Front Ophthalmol (Lausanne)
November 2023
Department of Vision Sciences, University of Houston College of Optometry, Houston, TX, United States.
Electrical synapses, formed of gap junctions, are ubiquitous components of the central nervous system (CNS) that shape neuronal circuit connectivity and dynamics. In the retina, electrical synapses can create a circuit, control the signal-to-noise ratio in individual neurons, and support the coordinated neuronal firing of ganglion cells, hence, regulating signal processing at the network, single-cell, and dendritic level. We, the authors, and Steve Massey have had a long interest in gap junctions in retinal circuits, in general, and in the network of photoreceptors, in particular.
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