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Direct screening of a target-specific covalent binder: stringent regulation of warhead reactivity in a matchmaking environment. | LitMetric
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Direct screening of a target-specific covalent binder: stringent regulation of warhead reactivity in a matchmaking environment.

Yudai Tabuchi Takahito Watanabe Riku Katsuki Yuji Ito Masumi Taki

Chem Commun (Camb)

Department of Engineering Science, Bioscience and Technology Program, The Graduate School of Informatics and Engineering, The University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan.

Published: June 2021

A peptide-type covalent binder for a target protein was obtained by direct and stringent screening of a warhead-modified peptide library on the robust T7 phage. The aryl fluorosulfate (fosylate) warhead was activated only in a matchmaking microenvironment created between the target protein and an appropriate peptide during the reactivity/affinity-based co-selection process of extended phage display.

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 Source
http://dx.doi.org/10.1039/d1cc01773jDOI Listing

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