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Proximity-induced exponential amplification reaction triggered by proteins and small molecules. | LitMetric

Proximity-induced exponential amplification reaction triggered by proteins and small molecules.

Chem Commun (Camb)

State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, and School of Medicine, Nankai University, Tianjin 300071, P. R. China.

Published: May 2021

We proposed a method to regulate nucleic acid polymerization by proximity and designed an ultrasensitive biosensor based on proximity-induced exponential amplification reaction for proximity assay of proteins (streptavidin) and small molecules (adenosine triphosphate), which allows us to detect a variety of interesting targets by simply changing the binding sites of DNA.

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Source
http://dx.doi.org/10.1039/d1cc00583aDOI Listing

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