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| http://dx.doi.org/10.1007/s00441-021-03472-1 | DOI Listing |
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Clinical Manifestations.
Alzheimers Dement
December 2024
University of Kentucky, Lexington, KY, USA.
Background: Disruption of sleep and circadian rhythms are associated with cognitive decline, preclinical Alzheimer's Disease (AD) pathology, and increased risk of dementia. Alleviating circadian rhythm and sleep disruption may improve cognition and reduce the progression of AD and related dementias (ADRD). Time-restricted eating (TRE), a circadian behavioral intervention that corrects disrupted eating rhythms by aligning food intake to the daytime, has demonstrated improvements in metabolic dysfunction and sleep quality.
View Article and Find Full Text PDF[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.].
Adv Gerontol
January 2025
Belgorod State National Research University, 85 build. 10 Pobedy str., Belgorod 308015, Russian Federation, e-mail:
Article Synopsis
- The review summarizes long-term research by the Saint-Petersburg Institute of Bioregulation and Gerontology on the biological activity of peptide bioregulators and compares findings from domestic and international studies.
- Russian scientists have taken the lead in using buccal epithelium as a diagnostic marker for age-related diseases, highlighting their significant contributions in this field.
- The research reveals that peptides from the epiphysis can enhance melatonin secretion and influence circadian rhythms in the elderly by regulating gene expression and reducing harmful protein synthesis, suggesting their potential as therapeutic agents for age-related issues.
Light Environment of Arctic Solstices is Coupled With Melatonin Phase-Amplitude Changes and Decline of Metabolic Health.
J Pineal Res
January 2025
Department of Integrated Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA.
Light environment in the Arctic differs widely with the seasons. Studies of relationships between objectively measured circadian phase and amplitude of light exposure and melatonin in community-dwelling Arctic residents are lacking. This investigation combines cross-sectional (n = 24-62) and longitudinal (n = 13-27) data from week-long actigraphy (with light sensor), 24-h salivary melatonin profiles, and proxies of metabolic health.
View Article and Find Full Text PDFAnalytic solutions for the circadian oscillator characterize cycle dynamics and its robustness.
J Math Biol
December 2024
Macbes team, INRAE, CNRS, Centre Inria d'Université Côte d'Azur, Sophia Antipolis, France.
Circadian clocks form a fundamental mechanism that promotes the correct behavior of many cellular and molecular processes by synchronizing them on a 24 h period. However, the circadian cycles remain difficult to describe mathematically. To overcome this problem, we first propose a segmentation of the circadian cycle into eight stages based on the levels of expression of the core clock components CLOCK:BMAL1, REV-ERB and PER:CRY.
View Article and Find Full Text PDFFrequency, clinical presentation and management of primary amenorrhea in a tertiary care setting.
Pak J Med Sci
December 2024
Riffat Jaleel, FCPS, Department of Obstetrics and Gynaecology Unit II, D. Ruth K. M. Pfau Civil Hospital Karachi and, Dow University of Health Sciences, Karachi, Pakistan.
Objective: We aimed to determine frequency, clinical presentation, etiology and management in patients presenting with primary amenorrhea in tertiary care setting.
Method: This was a case series conducted in outpatient Department of Gynecology and Obstetrics unit II, Dr. Ruth K.
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