AI Article Synopsis
- - Gemcitabine and Docetaxel (GEM/DTX) are common chemotherapy drugs used for soft tissue sarcomas but their effectiveness against malignant rhabdoid tumors (MRTs) is not well-studied.
- - In a small study, GEM/DTX was used as salvage therapy for relapsed MRTs, showing partial responses in 3 out of 4 patients, including two with malignant rhabdoid tumors of the kidney.
- - While GEM/DTX shows potential for treating resistant MRTs, there are specific side effects that require careful monitoring, such as localized edema and pleural effusion.
Article Abstract
Gemcitabine and Docetaxel(GEM/DTX)are well known chemotherapeutic drugs for the treatment of soft tissue sarcomas. However, the efficacy of these drugs in the treatment of malignant rhabdoid tumors(MRTs)has not been well described. We used GEM/DTX as salvage chemotherapy for relapsed and refractory MRTs, including 2 patients with malignant rhabdoid tumor of the kidney(MRTK)and 2 with atypical teratoid rhabdoid tumor(ATRT). At the best, partial response was observed in 3 patients(2 MRTK and 1 ATRT). The remaining patient with ATRT had stable disease. Localized edema in the field of recent radiation therapy was discovered in 2 patients. In addition, one had pleural effusion without any evidence of tumor progression. GEM/DTX can be used as a potential chemotherapeutic drug for relapsed or refractory MRTs, although attention should be paid to its unique adverse events.
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