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Intelligent Microneedles Patch with Wireless Self-Sensing and Anti-Infective Actions.
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December 2024
Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, 130012, China.
Traditional microneedle (MN) technology offers unique advantages in treating wound infections; however, its single-function design lacks the capability for real-time monitoring of wound conditions, often resulting in uncontrolled drug release. Herein, an anti-infective and intelligent MN patch (SP-CSMN) integrating three functional modules is developed, including temperature monitoring, Bluetooth wireless communication, and responsive drug release. The patch employed chitosan (CS) as a porous substrate, filled with temperature-sensitive poly(N-isopropylacrylamide) (PNIPAM) to encapsulate and release the antibiotic rifampicin.
View Article and Find Full Text PDFRotational osteotomy of forearm bones for treatment of congenital radioulnar synostosis in children.
J Orthop Surg Res
December 2024
The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, China.
Background: Congenital radioulnar synostosis (CRUS) is a rare upper limb deformity characterized by impaired rotational movement of the forearm. Rotational osteotomy is a commonly employed surgical procedure for treatment. This study aimed to analyze its surgical efficacy in treating CRUS in children.
View Article and Find Full Text PDFExpression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer's, and liver cancer.
Eur J Med Res
December 2024
Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, No. 7 Weiwu, Zhengzhou, 450003, Henan, China.
Background: Nicastrin, a subunit of the γ-secretase complex, is encoded by the NCSTN gene and regulates notch signaling, it is involved in the pathogenesis of hidradenitis suppurativa (HS), Alzheimer disease (AD), and liver cancer. However, the animal models for studying HS are relatively scarce.
Methods: CRISPR/Cas-mediated genetic engineering was used to generate targeted knockout offspring mice (C57BL/6J).
Trend and forecast of measles disease, in East Gojjam Zone, Amhara Region, Northwest Ethiopia, 2023: a crossectional study.
BMC Res Notes
December 2024
Department of Statistics, College of Natural and Computational Sciences, Gambella University, Gambella, Ethiopia.
Background: Measles is a very contagious illness that can be clinically diagnosed and intervened quickly. It is caused by the measles virus Morbillivirus. The disease has a case fatality rate of 5% to 10% in the sub-Saharan region.
View Article and Find Full Text PDFAngiosarcoma associated with Kasabach-Merritt syndrome presenting with typical signs and symptoms of pulmonary tuberculosis: a case report.
J Med Case Rep
December 2024
Shifa International Hospital/Shifa Tameer e Millat University, Islamabad, Pakistan.
Background: Angiosarcoma is a rapidly proliferating vascular tumor that originates in endothelial cells of vessels. Rarely, it can be associated with consumptive coagulopathy due to disseminated intravascular coagulation eventually leading to thrombocytopenia and microangiopathic hemolytic anemia. This specific manifestation is termed Kasabach-Merritt syndrome.
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