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The Unripe Carob Extract ( L.) as a Potential Therapeutic Strategy to Fight Oxaliplatin-Induced Neuropathy.
Nutrients
December 2024
Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, 50139 Florence, Italy.
Background: Oxaliplatin-induced neuropathy (OIN) is a severe painful condition that strongly affects the patient's quality of life and cannot be counteracted by the available drugs or adjuvants. Thus, several efforts are devoted to discovering substances that can revert or reduce OIN, including natural compounds. The carob tree, L.
View Article and Find Full Text PDFTwo Nonimmediate Reactions to Oxaliplatin and Docetaxel Confirmed by Lymphocyte Transformation Test and Treated With Successful Rapid Desensitization Procedures.
J Investig Allergol Clin Immunol
December 2024
Biochemistry-Research Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
Effect of Advillin Knockout on Diabetic Neuropathy Induced by Multiple Low Doses of Streptozotocin.
J Physiol Investig
December 2024
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Advillin is an actin-binding protein involved in regulating the organization of actin filaments and the dynamics of axonal growth cones. In mice, advillin is exclusively expressed in somatosensory neurons, ubiquitously expressed in all neuron subtypes during neonatal ages and particularly enriched in isolectin B4-positive (IB4+) non-peptidergic neurons in adulthood. We previously showed that advillin plays a key role in axon regeneration of somatosensory neurons during peripheral neuropathy.
View Article and Find Full Text PDFContribution of T-type calcium channel isoforms to cold and mechanical sensitivity in naïve and oxaliplatin-treated mice of both sexes.
Br J Pharmacol
December 2024
Department of Clinical Neurosciences, Cumming School of Medicine, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.
Article Synopsis
- Oxaliplatin, a chemotherapy drug, can cause a painful condition called oxaliplatin-induced peripheral neuropathy (OIPN), and this study examines the role of T-type calcium channels in this process.
- The research involved chronic treatment of mice with oxaliplatin to assess their pain responses and changes in calcium channel expression, while also testing the effects of specific channel blockers on cold sensitivity.
- Results indicated that T-type channels contribute to both mechanical and cold hypersensitivity differently in male and female mice, suggesting that targeting these channels might help manage OIPN pain without causing additional cold sensitivity issues.
Role of TRPA1 in Painful Cold Hypersensitivity.
Adv Exp Med Biol
September 2024
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Article Synopsis
- * Research indicates that oxaliplatin, a chemotherapy drug, increases TRPA1's sensitivity to both chemical triggers and reactive oxygen species (ROS), which play a role in pain generation.
- * The study highlights that oxaliplatin disrupts a specific protein's action, making TRPA1 responsive to cold, despite its general insensitivity, thereby linking ROS signaling to cold sensitivity and pain in conditions like peripheral vascular impairment.
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