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The protective effects of the and mushrooms on histopathology of carbon tetrachloride induced oxidative stress in rats. | LitMetric
We investigated the protective effects of and supplementation against carbon tetrachloride (CCI) induced oxidative stress by measuring levels of adenosine deaminase (ADA) and myeloperoxidase (MPO), and by observing histopathological changes in liver and kidney tissues of rats. We divided 36 rats into six groups: control, CCl, , CCl + , and CCl + . We found that administration of CCI, , and CCl + increased MPO and ADA levels. We observed severe hepato-renal degenerative and necrotic lesions in the CCI, and CCl + groups. Severe lesions of the liver and kidney were not observed with administration. CCI induced hepato-renal lesions were ameliorated by extract supplementation. could be an important dietary antioxidant for preventing histologic lesions in liver and kidney due to CCI induced oxidative stress in rats.
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