AI Article Synopsis
- Elevated ATP levels in cystic fibrosis (CF) patients may provide health benefits, particularly in fighting advanced solid tumors.
- Research indicates that intravenous ATP can restore ATP levels in cancer patients, leading to improvements in their health and quality of life.
- The authors propose that the high ATP levels in CF patients could also enhance their survival rates after contracting COVID-19, and they explore the potential clinical applications of this hypothesis.
Article Abstract
Systemic pools of ATP are elevated in individuals homozygous for cystic fibrosis (CF) as evidenced by elevated blood and plasma ATP levels. This elevated ATP level seems to provide benefit in the presence of advanced solid tumors (Abraham et al., Nature Medicine 2(5):593-596, 1996). We published in this journal a paper showing that IV ATP can elevate the depleted ATP pools of advanced cancer patients up to levels found in CF patients with subsequent clinical, biochemical, and quality of life (QOL) improvements (Rapaport et al., Purinergic Signalling 11(2): 251-262, 2015). We hypothesize that the elevated ATP levels seen in CF patients may be benefiting CF patients in another way: by improving their survival after contracting COVID-19. We discuss here the reasoning behind this hypothesis and suggest how these findings might be applied clinically in the general population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107773 | PMC |
| http://dx.doi.org/10.1007/s11302-021-09771-0 | DOI Listing |
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