() is known to cause several gastroduodenal diseases including chronic Gastritis, Peptic Ulcer disease and Gastric Cancer. Virulent genes of like , are known to be responsible for the disease pathogenesis. However, these virulence genes are not always found to be associated with disease outcome in all populations around the world. Tumor necrosis factor alpha inducing protein is a newly discovered virulence gene of and is an inducer of certain cytokines and chemokines that are responsible for causing stomach cancer. Therefore, we conducted a study, which aims to find the prevalence of tipα gene in the Indian patients with gastroduodenal symptoms, and its association with related gastroduodenal diseases. 267 clinical isolates are included in our study for finding the prevalence of gene and its association with and gene using PCR assay. The current study shows that the prevalence rate of gene is 59.9%. Our study has found a significant association ( < 0.05) of gene with Non Ulcer Dyspepsia (NUD) and an association of and s1m1 with Gastritis and Duodenal Ulcer. Our study demonstrates for the first time the presence of as virulence factor of strain in Indian population isolated from patients suffering from gastroduodenal diseases. Further, is significantly associated with NUD but not with other gastroduodenal diseases in India.
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| http://dx.doi.org/10.1007/s13205-021-02804-w | DOI Listing |
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