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Glycated Albumin Triggers an Inflammatory Response in the Human Airway Epithelium and Causes an Increase in Ciliary Beat Frequency. | LitMetric

Glycated Albumin Triggers an Inflammatory Response in the Human Airway Epithelium and Causes an Increase in Ciliary Beat Frequency.

Front Physiol

Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.

Published: April 2021

AI Article Synopsis

  • Inflammation in airway epithelial cells is crucial for understanding respiratory diseases, as damage to the pulmonary barrier allows serum proteins to enter the airways.
  • Human glycated albumin (GA) triggers an inflammatory response by inducing the secretion of IL-8 from airway epithelial cells, with this response being significantly more potent than other known stimulants like TNF or LPS.
  • GA not only promotes IL-8 secretion but also increases the ciliary beat frequency in airway epithelial cells, suggesting its role in airway inflammation and the need for further research to determine its binding mechanisms.

Article Abstract

The role of inflammation in airway epithelial cells and its regulation are important in several respiratory diseases. When disease is present, the barrier between the pulmonary circulation and the airway epithelium is damaged, allowing serum proteins to enter the airways. We identified that human glycated albumin (GA) is a molecule in human serum that triggers an inflammatory response in human airway epithelial cultures. We observed that single-donor human serum induced IL-8 secretion from primary human airway epithelial cells and from a cystic fibrosis airway cell line (CF1-16) in a dose-dependent manner. IL-8 secretion from airway epithelial cells was time dependent and rapidly increased in the first 4 h of incubation. Stimulation with GA promoted epithelial cells to secrete IL-8, and this increase was blocked by the anti-GA antibody. The IL-8 secretion induced by serum GA was 10-50-fold more potent than TNF or LPS stimulation. GA also has a functional effect on airway epithelial cells , increasing ciliary beat frequency. Our results demonstrate that the serum molecule GA is pro-inflammatory and triggers host defense responses including increases in IL-8 secretion and ciliary beat frequency in the human airway epithelium. Although the binding site of GA has not yet been described, it is possible that GA could bind to the receptor for advanced glycated end products (RAGE), known to be expressed in the airway epithelium; however, further experiments are needed to identify the mechanism involved. We highlight a possible role for GA in airway inflammation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102681PMC
http://dx.doi.org/10.3389/fphys.2021.653177DOI Listing

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