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Vascular ageing manifestations and hypertension in the community.
Am J Prev Cardiol
March 2025
Université Paris Cité, INSERM U970, Paris Cardiovascular Research Centre, Team Integrative epidemiology of cardiovascular diseases, Paris, France.
Objective: To investigate the association between joint manifestations of vascular ageing (VA) and hypertension.
Methods: We used baseline (2008-2012) and follow-up data (up to 2024) from the Paris Prospective Study III, a French cohort of 10,157 participants. Prevalent and incident hypertension were determined at baseline (blood pressure ≥140/90 mmHg or on medication) and at 2, 4, 6, 8 and 10 years of follow-up (self-reported antihypertensive treatment).
Cardiac pathology associated with hypertension and chronic kidney disease in aged cats.
J Comp Pathol
January 2025
Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK. Electronic address:
Hypertension is a common condition in older cats, often secondary to chronic kidney disease (CKD). Although the heart is one of the organs damaged by hypertension, the pathology of the feline hypertensive (HT) heart has been poorly studied. The aim of this retrospective study was to describe the gross and microscopic pathology of hearts obtained from cats at post-mortem examination and to compare cats diagnosed with hypertension with cats of similar age and kidney function for which antihypertensive treatment was not deemed clinically necessary.
View Article and Find Full Text PDFAssociation of Duration of Recognized Hypertension and Stroke Risk: The REGARDS Study.
Stroke
January 2025
Department of Epidemiology (P.M., V.J.H.), School of Public Health, University of Alabama at Birmingham.
Background: The focus for reducing hypertension-related cardiovascular disease is the management of blood pressure. Limited data are available on the potential benefit of delaying the onset of hypertension.
Methods: Stroke-free Black and White participants from the REGARDS cohort study (Reasons for Geographic and Racial Differences in Stroke; recruited 2003-2007) were followed through 2022 for incident stroke events.
Systemic alpha-1 adrenergic receptor inhibition reduces sperm damage in adult and aging spontaneously hypertensive rats.
Sci Rep
November 2024
Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 3o Floor, Room 319, Butanta, SP, 05508000, Brazil.
Article Synopsis
- * In spontaneously hypertensive rats (SHRs), researchers found lower sperm concentration, motility, and higher acrosome damage, with SHRs showing elevated blood pressure across different ages.
- * Treatment with prazosin, which blocks α1-adrenergic receptors, improved sperm concentration and motility in hypertensive rats, but did not help with acrosome damage, highlighting the impact of hypertension on sperm quality.
Proteomic and phosphoproteomic identified structural and functional changes in the aorta associate with age-dependent hypertension in male Sprague Dawley rats.
Physiol Genomics
November 2024
Emory University School of Medicine, Department of Medicine, Division of Cardiology, Atlanta, GA, USA.
Hypertension affects 1 in 2 U.S. adults and hypertension prevalence increases with aging.
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