This study aimed to investigate the function of estrogen receptors (ERs) in myoregeneration and intermuscular adipogenesis. Ovariectomized (OVX) ERα knockout (KO) mice and ERβ KO mice were used to assess the effect of estrogen on the myoregenerative process. Tibialis anterior muscle was collected on days 7, 10, and 14 after cardiotoxin injection to assess myotube morphology and adipogenesis area. Regenerated myotubes from OVX-ERβ KO mice were consistently smaller in diameter than those from OVX-ERα KO and OVX-wild-type mice, whereas the adipogenesis area of OVX-ERβ KO mice was consistently greater than that of the other types. Therefore, ERβ may be an influential factor in promoting myoregeneration and adipogenesis inhibition compared to ERα.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349812PMC
http://dx.doi.org/10.1292/jvms.20-0696DOI Listing

Publication Analysis

Top Keywords

estrogen receptors
8
intermuscular adipogenesis
8
adipogenesis area
8
ovx-erβ mice
8
mice consistently
8
mice
6
adipogenesis
5
absence estrogen
4
receptors delays
4
delays myoregeneration
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!