AI Article Synopsis
- Cancer-testicular Antigens (CTAs) are proteins normally found in male reproductive tissues but can be re-expressed in various cancers, influencing tumor growth and metastasis.
- Two specific CTAs, Semenogelin 1 and 2 (SEMG1 and SEMG2), are key components of seminal fluid and play a role in sperm function.
- This review focuses on the functions of SEMGs in both the reproductive system and their implications in different types of cancer, given the lack of research on their role in malignancies.
Article Abstract
Cancer-testicular Antigens (CTAs) belong to a group of proteins that under normal conditions are strictly expressed in a male's reproductive tissues. However, upon malignisation, they are frequently re-expressed in neoplastic tissues of various origin. A number of studies have shown that different CTAs affect growth, migration and invasion of tumor cells and favor cancer development and metastasis. Two members of the CTA group, Semenogelin 1 and 2 (SEMG1 and SEMG2, or SEMGs) represent the major component of human seminal fluid. They regulate the motility and capacitation of sperm. They are often re-expressed in different malignancies including breast cancer. However, there is almost no information about the functional properties of SEMGs in cancer cells. In this review, we highlight the role of SEMGs in the reproductive system and also summarize the data on their expression and functions in malignant cells of various origins.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106676 | PMC |
| http://dx.doi.org/10.1038/s41420-021-00482-4 | DOI Listing |
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