AI Article Synopsis
- The laboratory rat is increasingly used in studies of physiology, behavior, and human diseases due to its relevance and advantages over traditional models like mice.
- The mononuclear phagocyte system (MPS), which includes cells like monocytes and macrophages, plays a critical role in development, immunity, and managing inflammation.
- This article examines the current understanding and available research tools relating to the MPS in rats, highlighting their development, regulation, and diversity compared to existing knowledge from mouse studies.
Article Abstract
The laboratory rat continues to be the model of choice for many studies of physiology, behavior, and complex human diseases. Cells of the mononuclear phagocyte system (MPS; monocytes, macrophages, and dendritic cells) are abundant residents in every tissue in the body and regulate postnatal development, homeostasis, and innate and acquired immunity. Recruitment and proliferation of MPS cells is an essential component of both initiation and resolution of inflammation. The large majority of current knowledge of MPS biology is derived from studies of inbred mice, but advances in technology and resources have eliminated many of the advantages of the mouse as a model. In this article, we review the tools available and the current state of knowledge of development, homeostasis, regulation, and diversity within the MPS of the rat.
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| http://dx.doi.org/10.4049/jimmunol.2100136 | DOI Listing |
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