Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bpsc.2021.03.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury.
Sci Rep
January 2025
Division of Anaesthesia, University of Cambridge, Cambridge, UK.
Practices for controlling intracranial pressure (ICP) in traumatic brain injury (TBI) patients admitted to the intensive care unit (ICU) vary considerably between centres. To help understand the rational basis for such variance in care, this study aims to identify the patient-level predictors of changes in ICP management. We extracted all heterogeneous data (2008 pre-ICU and ICU variables) collected from a prospective cohort (n = 844, 51 ICUs) of ICP-monitored TBI patients in the Collaborative European NeuroTrauma Effectiveness Research in TBI study.
View Article and Find Full Text PDFReview of Functional Cranioplasty and Implantable Neurotechnology.
J Craniofac Surg
December 2024
Department of Otolaryngology-Head and Neck Surgery, Neuroplastic and Reconstructive Surgery, Naval Medical Center Portsmouth, Portsmouth, VA.
Cranioplasty for secondary reconstruction of cranial defects has historically focused on simply replacing the missing cranial bone to restore cerebral protection and fluid dynamics, but recent innovations have led to the development of customized cranial implants that address both bone and soft tissue deficits while avoiding postoperative complications such as temporal hollowing. In addition, customized cranial implants have incorporated implantable neurotechnology like ventriculostomy shunts, intracranial pressure monitoring devices, and medicine delivery systems within low-profile designs to convert previously "basic" implants into "smart" implants for added functionality. These "smart" implants aim to reduce complications and improve patient outcomes by leveraging the cranial space to house advanced technologies, providing benefits such as real-time biosensing, and treatment of chronic neurological conditions.
View Article and Find Full Text PDFHuman Genetic Evidence to Inform Clinical Development of IL-6 Signaling Inhibition for Abdominal Aortic Aneurysm.
Arterioscler Thromb Vasc Biol
December 2024
Sequoia Genetics, London, United Kingdom (S.B., H.T.C., D.G.).
Article Synopsis
- Abdominal aortic aneurysm (AAA) is a major health issue with no effective medical treatments, so researchers are exploring IL-6 signaling inhibition as a potential therapy.
- The study analyzed genetic data from large cohorts, finding strong associations between genetic variants linked to IL-6 signaling and reduced AAA risk.
- The results suggest that targeting IL-6 signaling could be a viable approach for AAA treatment, though it may not be effective for other aneurysm types.
Sex differences in brain MRI using deep learning toward fairer healthcare outcomes.
Front Comput Neurosci
November 2024
Department of Electrical and Software Engineering, University of Calgary, Calgary, AB, Canada.
Article Synopsis
- - This study uses deep learning to analyze sex differences in brain MRI data, involving 3D images from four diverse datasets while maintaining balanced representation in sex and demographics.
- - A Convolutional Neural Network model achieved 87% accuracy in sex classification without adjusting for total intracranial volume, revealing some biases related to brain size but performing better with overlapping TIV distributions.
- - The research highlighted key brain regions important for sex differentiation and aims to inform strategies for reducing bias in medical imaging, ultimately contributing to fairer AI algorithms and healthcare outcomes.
Monitoring Guideline Adherence in Severe Traumatic Brain Injury.
Stud Health Technol Inform
November 2024
CHU Rennes, INSERM, LTSI-UMR 1099, Univ Rennes, 35000 Rennes, France.
Traumatic brain injuries (TBI) significantly impact global health, often resulting in death or long-term disability. We developed a quality dashboard to monitor adherence to severe TBI guidelines, leveraging data from Rennes University Hospital's clinical data warehouse collected between January 2020 and December 2023. We included 193 patients from the surgical ICU who were over 18 years old and excluded those without adequate intracranial pressure (ICP) monitoring data.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!