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| http://dx.doi.org/10.1016/j.bpsc.2021.02.007 | DOI Listing |
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Previous characterization of the genome and transcriptome of glioblastoma (GBM) has revealed molecular alterations that potentially drive GBM pathogenesis and heterogeneity . These open-resources are evolving, such as The Cancer Genome Atlas (TCGA) and The Cancer Imaging Atlas (TCIA) at the National Institute of Health comprising a large cohort of molecular and MRI data. Yet, no report deciphers the link between molecular signatures and MRI-classified GBM.
View Article and Find Full Text PDFAstrocytes safeguard the homeostasis of the central nervous system. Despite their prominent morphological plasticity under conditions that challenge the brain's adaptive capacity, the classification of astrocytes, and relating their molecular make-up to spatially devolved neuronal operations that specify behavior or metabolism, remained mostly futile. Although it seems unexpected in the era of single-cell biology, the lack of a major advance in stratifying astrocytes under physiological conditions rests on the incompatibility of 'neurocentric' algorithms that rely on stable developmental endpoints, lifelong transcriptional, neurotransmitter, and neuropeptide signatures for classification with the dynamic functional states, anatomic allocation, and allostatic plasticity of astrocytes.
View Article and Find Full Text PDFUnveiling Hypothalamic Molecular Signatures via Retrograde Viral Tracing and Single-Cell Transcriptomics.
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Department of Biochemistry & Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea.
Despite the importance of hypothalamic neurocircuits in regulating homeostatic and survival-related behaviors, our understanding of the intrinsic molecular identities of neural components involved in these complex multi-synaptic interactions remains limited. In this study, we constructed a Cre recombinase-dependent pseudorabies virus (PRVs) capable of crossing synapses, coupled with transcriptome analysis of single upstream neurons post-infection. By utilizing this retrograde nuclear Connect-seq (nuConnect-seq) approach, we generated a single nuclei RNA-seq (snRNA-seq) dataset of 1,533 cells derived from the hypothalamus of CRH-IRES-Cre (CRH-Cre) mice.
View Article and Find Full Text PDFDiverse Clinical Phenotypes of -Related Disorders and Multiple Functional Domains of CASK Protein.
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Department of Neuroinnovation, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Matsumoto 390-8621, Japan.
-related disorders are a form of rare X-linked neurological diseases and most of the patients are females. They are characterized by several symptoms, including microcephaly with pontine and cerebellar hypoplasia (MICPCH), epilepsy, congenital nystagmus, and neurodevelopmental disorders. Whole-genome sequencing has identified various mutations, including nonsense and missense mutations, from patients with -related disorders, revealing correlations between specific mutations and clinical phenotypes.
View Article and Find Full Text PDFDNA methylation in cocaine use disorder-An epigenome-wide approach in the human prefrontal cortex.
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Article Synopsis
- Cocaine use disorder (CUD) leads to significant changes in the brain, with suspected involvement of epigenetic factors, but most research so far has focused on animal studies rather than humans.
- This study analyzed DNA methylation in the brains of individuals with and without CUD, finding 20 differentially methylated regions (DMRs) linked to gene activity related to drug behavior.
- Although no direct epigenome-wide significance was found for any particular gene, a trend of accelerated biological aging was observed in CUD individuals, suggesting potential long-term impacts of the disorder on brain health.
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