Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2165/00003495-198800352-00047 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Population pharmacokinetic modeling of ceftriaxone in cerebrospinal fluid in children: should we be using once- or twice-daily dosing for meningitis?
Antimicrob Agents Chemother
November 2024
Department of General Medicine and Laboratory Services, The Royal Children's Hospital Melbourne, Parkville, Australia.
Article Synopsis
- Guidelines suggest giving kids with bacterial meningitis a medicine called ceftriaxone in certain doses.
- Researchers studied how well this medicine enters the brain's protective fluid in kids and found that the once-daily method works better than the twice-daily method for some bacteria.
- They learned that while the once-a-day dose is better, neither dose worked well enough for treating all kinds of meningitis.
In vivo biodistribution and ototoxicity assessment of cationic liposomal-ceftriaxone via noninvasive trans-tympanic delivery in chinchilla models: Implications for otitis media therapy.
Int J Pediatr Otorhinolaryngol
March 2024
Joint Department of Biomedical Engineering, Medical College of Wisconsin and Marquette University, Milwaukee, WI, USA. Electronic address:
Objectives: We report the in vivo biodistribution and ototoxicity of cationic liposomal-ceftriaxone (CFX) delivered via ear drop formulation in adult chinchilla.
Methods: CFX was encapsulated in liposomes with size of ∼100 nm and surface charge of +20 mV. 100 μl liposomes or free drug was applied twice daily in both external ear canals of adult chinchillas for either 3 or 10 days.
2023 Korean Association of Urogenital Tract Infection and Inflammation guidelines for gonococcal infection.
Investig Clin Urol
January 2024
Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
The incidence of gonorrhea has increased significantly in recent years in the United States, especially among sexually active twenty-year-olds. Although the incidence of gonorrhea has decreased in Korea since the early 2000s, it is still common among people in their twenties. Nucleic acid amplification test (NAAT) is the most sensitive diagnostic test for detecting gonococcal infection.
View Article and Find Full Text PDFChallenges of Antibiotic Formulations and Administration in the Treatment of Bloodstream Infections in Children Under Five Admitted to Kisantu Hospital, Democratic Republic of Congo.
Am J Trop Med Hyg
December 2023
Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Article Synopsis
- Severe bacterial infections in children require quick and effective antibiotic treatment, but challenges were identified in a study at a Kisantu hospital on non-typhi Salmonella bloodstream infections.
- While 98.4% of children received antibiotics, there were significant issues with timing, administration, and dosing accuracy, with only 78.3% receiving antibiotics on the day of admission.
- Problems included the use of inappropriate administration practices, poor-quality oral formulations, and a lack of essential dosing instructions, highlighting an urgent need for improvements in antibiotic management for pediatric care.
A Case of Lyme Disease Presenting as Bilateral Panuveitis.
Ocul Immunol Inflamm
September 2024
Department of Ophthalmology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea.
Here, we describe a case of Lyme disease presenting as bilateral panuveitis. A 25-year-old woman presented to our clinic with decreased visual acuity of 20/320 and 20/160 in the right and left eye, respectively. An ophthalmic examination revealed the presence of anterior chamber cells 3+, vitreous cells 1+, vitreous haziness 2+/1+, and retinal infiltration in both eyes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!