AI Article Synopsis
- This study investigates the heart's left ventricular mechanics in patients with non-compaction (LVNC) using strain analysis through echocardiography, focusing on how these mechanics relate to future cardiovascular events.
- Researchers analyzed data from 55 LVNC patients and 55 control subjects, finding that various measures of heart function, such as global longitudinal strain (GLS) and circumferential strain (GCS), were significantly impaired in LVNC patients.
- The study concluded that specific strain measures like apical peak circumferential strain (APCS) and twist are strongly linked to cardiovascular events, providing valuable insights that could enhance the clinical evaluation of LVNC patients.
Article Abstract
Aims: This study aims at understanding left ventricular (LV) mechanics of non-compaction (LVNC) phenotype using echocardiographic strain analysis and at assessing the association of functional parameters with cardiovascular (CV) outcomes.
Methods And Results: Longitudinal (GLS) and circumferential strain (GCS) as well as rotation of the LV were analyzed in 55 LVNC patients and 55 matched controls. Cardiovascular outcomes were documented for a median follow-up duration of 6 years. GLS and GCS were impaired in LVNC. Similary, regional longitudinal and circumferential strain as well as twist were reduced. CV events occurred in 28 LVNC patients. Apical peak circumferential strain (APCS), peak systolic rotation of apical segments (APSR), and twist were strongly associated with events. This was independent of and incremental to LVEF and non-compacted to compacted myocardial thickness ratio (NC:C ratio). The association of twist with events was also independent of and slightly superior to GLS.
Conclusions: GLS, GCS, regional strain, and twist were impaired in LVNC. APCS, APSR, and twist exhibited strong association with CV events independent of and incremental to LVEF and NC:C ratio, and in case of twist even GLS. Thus, STE-derived parameters may complement the echocardiographic assessment of LVNC patients in clinical routine.
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| http://dx.doi.org/10.1016/j.ijcard.2021.05.004 | DOI Listing |
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