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Efficacy and Safety of Virtual Reality-Based Versus Traditional Emotion-to-Emotion Therapy for Treatment of Hwa-Byung: A Protocol for a Single-Center, Randomized, Assessor-Blind, Parallel-Group Clinical Trial.
Healthcare (Basel)
November 2024
Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University, Daejeon 34520, Republic of Korea.
Background: Hwa-Byung is a culturally bound syndrome prevalent in Korea, characterized by intense emotional distress and physical symptoms related to suppressed anger. Patients frequently report experiencing chest tightness, heat sensations, and globus pharyngeus (the sensation of a lump in the throat). These physical symptoms often accompany psychological distress and can exacerbate the sense of frustration and helplessness associated with the condition.
View Article and Find Full Text PDFCultural tightness and resilience against environmental shocks in nonindustrial societies.
Proc Natl Acad Sci U S A
December 2024
Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, TN 37996.
With climate change intensifying, building resilience against climate-related shocks is now a global imperative. Historically, many societies have faced natural hazards, with some adapting through specific social and cultural practices. Understanding these responses is key to developing modern sustainability strategies.
View Article and Find Full Text PDFA semi-permeable insert culture model for the distal part of the nephron with human and mouse tubuloid epithelial cells.
Exp Cell Res
January 2025
Department of Medical BioSciences, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:
Tubuloids are advanced in vitro models obtained from adult human or mouse kidney cells with great potential for modelling kidney function in health and disease. Here, we developed a polarized human and mouse tubuloid epithelium on cell culture inserts, namely Transwell™ filters, as a model of the distal nephron with an accessible apical and basolateral side that allow for characterization of epithelial properties such as leak-tightness and epithelial resistance. Tubuloids formed a leak-tight and confluent epithelium on Transwells™ and the human tubuloids were differentiated towards the distal part of the nephron.
View Article and Find Full Text PDFAdvanced Spray-Dried Inhalable Microparticles/Nanoparticles of an Innovative Mitophagy Activator for Targeted Lung Delivery: Design, Comprehensive Characterization, Human Lung Cell Culture, and In Vitro Aerosol Dispersion Performance.
ACS Pharmacol Transl Sci
November 2024
Florida International University Center for Translational Science, Port St. Lucie, Florida 34987, United States.
Urolithin A (UA) has demonstrated the ability to stimulate mitophagy and enhance mitochondrial and cellular health in skeletal muscles in humans after oral administration. It is hypothesized that targeted delivery of UA as inhaled dry powders to the lungs will enhance mitochondrial health through mitochondrial biogenesis. This study aimed to engineer inhalable excipient-free powders of UA as dry powder inhalers (DPIs) for targeted pulmonary delivery.
View Article and Find Full Text PDFThe Chinese Herbal Medicine Li Qi Huo Xue Di Wan Ameliorates Ischemia or Hypoxia-Induced Cardiac Injury and Remodeling in the Heart Through a Mechanism Involving Reduction of Necroptosis.
Environ Toxicol
November 2024
Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Li Qi Huo Xue Di Wan (LQHXDW), a Chinese herbal medicine, is commonly used to treat symptoms such as palpitations, chest tightness, chest pain, and shortness of breath. However, its potential to reduce ischemia or hypoxia-induced cardiac injury and remodeling, along with the precise mechanisms involved, remains unclear. This study aims to investigate the effects of LQHXDW on cardiac injury and remodeling induced by ischemia or hypoxia, both in vivo and in vitro, and to elucidate the underlying mechanisms.
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