AI Article Synopsis
- A study involving 121 Italian children with coeliac disease compared their HLA-DR and DQ antigen patterns to a control group from the same area.
- The results showed an increase in certain antigens, specifically DR3, DR7, and the combination of DR5/7, in the coeliac disease group.
- This suggests that specific combinations of DQ alpha and beta chains may predispose individuals to coeliac disease.
Article Abstract
One hundred and twenty-one Italian children with coeliac disease (CD) have been compared with a control population from the same geographical area for the distribution of HLA-DR and DQ antigens. The pattern of an increase in DR3, DR7, and of heterozygotes DR5/7 was associated with an excess of heterozygotes DQw2/DQw3 in the CD population. These findings suggest that epitopes determined by specific combinations of DQ alpha and beta chains (combinatorial determinants) predispose to the disease.
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