AI Article Synopsis
- The study developed a method to encapsulate volatile perfume in microcapsules using eco-friendly biopolymers, chitosan and Eudragit S100, achieving high encapsulation efficiency.
- The process involved emulsifying limonene in ethyl acetate with specific polymers, which formed a stable emulsion that solidified after freeze-drying.
- Results showed that the encapsulation efficiency exceeded 94%, with optimal performance at a 1:1 polymer ratio, allowing sustained release of the perfume for up to 120 hours.
Article Abstract
In this study, volatile perfume was encapsulated in microcapsules (MCs) via interpolyelectrolyte complexes (IPECs) of oppositely charged polymers, with high encapsulation efficiency, to be delivered in a sustained manner. Positively charged chitosan (CTS) and negatively charged Eudragit® S100 (ES100) were used as eco-friendly biopolymers. Limonene (LMN) was selected as the model perfume. First, the solution of LMN in ethyl acetate and poloxamer 407 (POX407) in acidic solution was emulsified using ultrasonication. CTS and ES100 were added in that particular order to form o/w emulsion. LMN-loaded microcapsules (LMN-MCs) were prepared by adjusting the pH and freeze-drying for solidification. The electrostatic interactions of CTS and ES100 to form IPECs were highly dependent on pH, changing in the microscopic images of emulsion droplets and zeta potential. The NH group of CTS and the COO group of ES100 caused the electrostatic interactions at a specific pH. The formation mechanism of LMN-MCs was successfully validated using instrumental analysis, charge density, and energy dispersive X-ray spectrometer (EDS) mapping. Encapsulation efficiency, loading content, and release rates of LMN-MCs varied according to the ratios of CTS and ES100, demonstrating optimal performance at a 1:1 ratio. The current LMN-MCs could provide a simple manufacturing process with high performance in terms of encapsulation efficiency (>94%), drug loading, yield and sustained release of volatile perfume for 120 h.
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| http://dx.doi.org/10.1016/j.ijpharm.2021.120672 | DOI Listing |
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