Hossain et al. (2021) show that human origin recognition complex subunit ORC1 and licensing factor CDC6 interact when the pre-replicative complex forms in G1. Short linear motifs (SLiMs) in intrinsically disordered regions (IDRs) mediate this interaction and its regulation by CDKs.
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| http://dx.doi.org/10.1016/j.molcel.2021.04.016 | DOI Listing |
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