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Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Otsuka America Pharmaceutical Inc., Princeton, NJ, USA.
Background: Language serves as a powerful tool in shaping perceptions and reinforcing societal norms. Current understanding suggests that the language used to describe dementia can impact how the condition is perceived, understood, and addressed within various cultural contexts. Further, language can play a pivot role in shaping caregiving practices, willingness to seek medical care, and the openness, or lack thereof, to speak about the condition.
View Article and Find Full Text PDFDisease foci of pharmaceutical research and development as reflected in applications for International Nonproprietary Names, 1953-2022.
Bull World Health Organ
January 2025
INN Programme and Classification of Medical Products, World Health Organization, 20 Avenue Appia, 1211Geneva, Switzerland.
Objective: To evaluate trends in pharmaceutical research and development, and to correlate these trends with global medical need.
Methods: We obtained details of proposed pharmaceutical substances from 1953 to 2022 from the International Nonproprietary Names (INN) database. We used the DrugBank and Cortellis databases to obtain the INN included in approved medicines over the same period.
Myoclonus After Cardiac Arrest: Need for Standardization-A Systematic Review and Research Proposal on Terminology.
Crit Care Med
November 2024
Department of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Member of the European Reference Network EpiCARE, Salzburg, Austria.
Objectives: Although myoclonus less than or equal to 72 hours after cardiac arrest (CA) is often viewed as a single entity, there is considerable heterogeneity in its clinical and electrophysiology characteristics, and its strength of association with outcome. We reviewed definitions, electroencephalogram, and outcome of myoclonus post-CA to assess the need for consensus and the potential role of electroencephalogram for further research.
Data Sources: PubMed, Embase, and Cochrane databases.
'Do they care?': a qualitative examination of patient perspectives on primary care clinician communication related to opioids in the USA.
BMJ Open
January 2025
Center for Pharmacy Innovation and Outcomes, Geisinger, Danville, Pennsylvania, USA
Objectives: This substudy's objectives were to (1) examine the transferability of a four archetype framework (simplified pattern of prototypical features) for patients at high risk for opioid use disorder (OUD) developed from a previous study with a similar population; (2) explore how patient preferences for terminology can inform clinician communication strategies for patients with OUD across archetypes and (3) explore how patient perceptions of opioid risks can inform clinician communication strategies across patient archetypes.
Design: This qualitative study collected data via semistructured phone interviews with patients about views on opioid-related discussions with primary care clinicians. Qualitative data were coded using the Rigorous and Accelerated Data Reduction technique and analysed via iterative inductive/deductive thematic analysis.
Dendrimers, Dendrons, and the Dendritic State: Reflection on the Last Decade with Expected New Roles in Pharma, Medicine, and the Life Sciences.
Pharmaceutics
November 2024
The National Dendrimer & Nanotechnology Center, NanoSynthons LLC, Mt. Pleasant, MI 48858, USA.
This perspective begins with an overview of the major impact that the dendron, dendrimer, and dendritic state (DDDS) discovery has made on traditional polymer science. The entire DDDS technology is underpinned by an unprecedented new polymerization strategy referred to as step-growth, amplification-controlled polymerization (SGACP). This new SGACP paradigm allows for routine polymerization of common monomers and organic materials into precise monodispersed, dendritic macromolecules (i.
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