Extensive fractionation of -hexane extract from the dried powdered-trunks of Pierre ex A.Froehner (Rubiaceae) led to the isolation of a new oleanane-skeleton triterpene, coffecanolic acid (), along with three known analogues sumaresinolic acid (), oleanolic acid (), and 3--acetyloleanolic acid (). The chemical structures were elucidated using FT-IR, 1D and 2D NMR and HR-ESI-MS data analysis. The isolated compounds were assayed for α-glucosidase inhibitory activity by determining their half-maximal inhibitory concentration (IC, µM). Compounds - exhibited higher inhibitory activities when compared with acarbose, a positive control. Compound was found to be the most potent molecule against α-glucosidase, with the IC = 83.0 ± 1.2 µM, which improved by 2.5-fold over acarbose (IC = 209.8 ± 0.3 µM) in this assay.[Formula: see text].
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