AI Article Synopsis
- A new zinc/strontium catalyst has been created for efficiently facilitating the asymmetric Michael addition reaction involving 3-acetoxy-2-oxindoles and β-ester enones.
- The reaction achieves high yields along with excellent enantioselectivities and diastereoselectivities.
- This method highlights the potential of 3-acetoxy-2-oxindoles as a stable precursor for producing chiral 3-substituted 3-hydroxy-2-oxindoles.
Article Abstract
A heterobimetallic zinc/strontium catalyst has been developed for the asymmetric Michael addition of 3-acetoxy-2-oxindoles to β-ester enones in high yields with excellent enantioselectivities and high diastereoselectivities. This process represents that 3-acetoxy-2-oxindoles can be used as a stable air- and base-tolerant precursor for chiral 3-substituted 3-hydroxy-2-oxindoles.
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| http://dx.doi.org/10.1021/acs.joc.1c00379 | DOI Listing |
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