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Objective: To assess the functioning of maternal, perinatal, neonatal and child death surveillance and response (DSR) mechanisms at a health district level.
Design: A framework of elements covering analysis of causes of death, and processes of review and response was developed and applied to the smallest unit of coordination (subdistrict) to evaluate DSR functioning. The evaluation design was a descriptive qualitative case study, based on observations of DSR practices and interviews.
Setting: Rural South African health district (subdistricts and district office).
Participants: A purposive sample of 45 front-line health managers and providers involved with maternal, perinatal, neonatal and child DSR. The DSR mechanisms reviewed included a system of real-time death reporting (24 hours) and review (48 hours), a nationally mandated confidential enquiry into maternal death and regular facility and subdistrict mortality audit and response processes.
Primary Outcome Measures: Functioning of maternal, perinatal, neonatal and child DSR.
Results: While DSR mechanisms were integrated into the organisational routines of the district, their functioning varied across subdistricts and between forms of DSR. Some forms of DSR, notably those involving maternal deaths, with external reporting and accounting, were more likely to trigger reactive fault-finding and sanctioning than other forms, which were more proactive in supporting evidence-based actions to prevent future deaths. These actions occurred at provider and system level, and to a limited extent, in communities.
Conclusions: This study provides an empirical example of the everyday practice of DSR mechanisms at a district level. It assesses such practice based on a framework of elements and enabling organisational processes that may be of value in similar settings elsewhere.
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http://dx.doi.org/10.1136/bmjopen-2020-043783 | DOI Listing |
Mol Biol Rep
December 2024
Department of Physiology, Faculty of Medicine, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Fibromyalgia (FM) is a complex, chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, and cognitive disturbances. Despite its prevalence, the pathophysiology of FM remains poorly understood, with current treatments often providing limited relief. Recent studies have suggested that metformin, a widely used antidiabetic drug, may have potential therapeutic benefits for chronic pain conditions, including FM.
View Article and Find Full Text PDFCells
November 2024
Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Fibromyalgia (FM) is a chronic and debilitating condition characterized by diffuse pain, often associated with symptoms such as fatigue, cognitive disturbances, and mood disorders. Metformin, an oral hypoglycemic agent, has recently gained attention for its potential benefits beyond glucose regulation. It has shown promise in alleviating neuropathic and inflammatory pain, suggesting that it could offer a novel approach to managing chronic pain conditions like FM.
View Article and Find Full Text PDFbioRxiv
November 2024
Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.
The interplay of RNA modifications - deposited by "writers", removed by "erasers" and identified by RNA binding proteins known as "readers" - forms the basis of the epitranscriptomic gene regulation hypothesis. Recent studies have identified the oncofetal RNA-binding protein IGF2BP3 as a "reader" of the N6-methyladenosine (mA) modification and crucial for regulating gene expression. Yet, how its function as a reader overlaps with its critical oncogenic function in leukemia remains an open question.
View Article and Find Full Text PDFSci Rep
November 2024
Laser Spectroscopy Group, Faculty of Electronics, Photonics and Microsystems, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, Wroclaw, 50-370, Poland.
We demonstrate the first successful stabilization of a dissipative soliton resonance (DSR) mode-locked (ML) laser source using straightforward techniques. Our setup employed a figure-8 (F8) resonator configuration and a nonlinear optical loop mirror (NOLM) to achieve stable mode-locking, generating 1064 nm rectangular pulses with a 3 ns duration at a repetition frequency of ~ 1 MHz. The pulses were boosted in an all-fiber amplifier chain and reached 30 µJ and 10 kW peak power per pulse at 30 W average output power.
View Article and Find Full Text PDFMaterials (Basel)
November 2024
School of Civil Engineering, Southwest Jiaotong University, Chengdu 610031, China.
In research aimed at improving the brittleness of WER (waterborne epoxy)-modified emulsified asphalt, commonly encountered issues are that the low-temperature performance of this type of asphalt becomes insufficient and the long curing time leads to low early strength. Matrix-emulsified asphalt was modified with WPU (waterborne polyurethane), WER, and DMP-30 (accelerator). Firstly, the performance changes of modified emulsified asphalt at different single-factor dosages were explored through conventional performance tests and assessments of its adhesion, tensile properties, and curing time.
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