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Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity. | LitMetric
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Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity.

Khamidulla Kamoldinov Jun Li Komila Eshbakova Shamansur Sagdullaev Gaoya Xu Yubo Zhou Jia Li Haji Akber Aisa

Phytochemistry

The State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi, 830011, China. Electronic address:

Published: July 2021

Phytochemical study on the ethanolic extract of the dried roots of Ferula samarkandica Korovin led to the isolation of nine undiscribed sesquiterpene coumarins, samarcandicins A-I, along with thirteen known sesquiterpene coumarins. Their structures were characterized by detailed spectroscopic analysis including NMR and HR-ESI-MS. Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11 cell with IC values of 3.94 ± 0.06 μM and 3.87 ± 0.10 μM, respectively, and nevskin and feshurin showed high inhibitory activity against mino cell with IC values of 1.48 ± 0.06 μM and 7.88 ± 0.60 μM, respectively.

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 Source
http://dx.doi.org/10.1016/j.phytochem.2021.112705DOI Listing

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