Recently developed quantitative models of psychopathology (i.e., Hierarchical Taxonomy of Psychopathology) identify an Antagonistic Externalizing spectrum that captures the psychological disposition toward criminal and antisocial behavior. The purpose of the present study was to examine relations between Antagonistic psychopathology (and associated Five-Factor model Antagonism/Agreeableness) and neural functioning related to social-cognitive Theory of Mind using a large sample ( = 973) collected as part of the Human Connectome Project (Van Essen et al., 2013a). No meaningful relations between Antagonism/Antagonistic Externalizing and Theory of Mind-related neural activity or synchrony were observed ( < .005). We conclude by outlining methodological considerations (e.g., validity of social cognition task and low test-retest reliability of functional biomarkers) that may account for these null results, and present recommendations for future research.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057509PMC
http://dx.doi.org/10.1017/pen.2020.12DOI Listing

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