ink, a flavoring and coloring agent in food, has attracted considerable attention due to its various pharmacological activities. Our previous study showed that the melanin of ink (MSMI) can alleviate oxidative damage and delay aging in D-galactose(D-gal)-induced aging mice. This study aimed to reveal the possible mechanisms of the anti-aging effect of MSMI. In this article, a comprehensive analysis of gas chromatography-mass spectrometry (GC-MS)-based metabolomics and microarray-based transcriptomics revealed that 221 mRNAs were differentially expressed and 46 metabolites were significantly changed in the anti-aging progress of MSMI. Integrated analysis of transcript and metabolic profiles indicated that MSMI mainly altered carbohydrate metabolism, lipid metabolism, and insulin signaling pathway. MSMI achieved anti-aging effects not only by reducing oxidative damage and sorbitol toxicity but also by regulating lipid metabolism, improving insulin sensitivity, and reducing the formation of advanced glycation end products (AGEs). Moreover, our findings firstly demonstrated that MSMI could increase the expression of interferon-induced proteins and might be a potential antiviral compound.
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http://dx.doi.org/10.18632/aging.202890 | DOI Listing |
ACS Appl Mater Interfaces
December 2024
Department of Chemistry "Giacomo Ciamician", University of Bologna, Via Selmi 2, Bologna 40126, Italy.
Cleaning unwanted paint layers represents a significant challenge in cultural heritage restoration, requiring high effectiveness, spatial precision, and nontoxic techniques. Cleaning vandalic acts or street art paints is particularly challenging because of insoluble varnishes, which are very resistant to traditional removal treatments. Here, for the first time, we employ the photothermal effect for cleaning an artwork, using electrospun nonwovens incorporated with melanin nanoparticles (NPs).
View Article and Find Full Text PDFColloids Surf B Biointerfaces
February 2025
Fisheries Department, Faculty of Marine Sciences, University of Hormozgan, Bandar Abbas, Iran. Electronic address:
Based on current research, a highly effective, completely biocompatible, and eco-friendly antifouling method was developed. Sepia pharaonis was used to synthesize melanin nanoparticles from its ink. To improve the anti-biofouling characteristics, CuO nanoparticles were synthesized from Padina sp.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Department of Dentistry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China. Electronic address:
Current approaches to managing diabetic oral ulcers are often inadequate in medical settings due to risks of bacterial contamination, oxidative harm, and hindered blood vessel growth during recovery. Here, we have developed a hydrogel (OQC2) consisting of oxidized dextran, quaternized chitosan, and melanin nanoparticles sourced from cuttlefish ink to effectively treat wounds from diabetic oral ulcers. Initially, by administering a straightforward local injection, a protection barrier forms over the mucosal injury, promptly stopping bleeding and neutralizing inflammatory agents.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao 266042, China; Qingdao Collaborative Innovation Center of Marine Bioactive Factor Health Food, Qingdao 266042, China; Qingdao Keda Future Biotechnology Co., Ltd., Qingdao 266042, China. Electronic address:
ACS Omega
September 2024
VNU University of Science, Vietnam National University, Hanoi 10000, Vietnam.
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