AI Article Synopsis
- Young premenopausal breast cancer patients may experience increased menopausal symptoms and risks of amenorrhea, infertility, and premature ovarian insufficiency due to adjuvant chemotherapy and other treatments.
- The report discusses menstrual disturbances tied to various treatments, including chemotherapy and endocrine therapy, and how these affect premenopausal women.
- Temporary ovarian suppression with GnRHa during chemotherapy has been shown to significantly lower the risk of chemotherapy-induced premature ovarian insufficiency and may help maintain fertility options such as embryo or oocyte cryopreservation.
Article Abstract
: For young premenopausal breast cancer (BC) patients, adjuvant chemotherapy and other anti-cancer treatments can increase the risk of menopausal symptoms and may cause chemotherapy-related amenorrhea (CRA), infertility and premature ovarian insufficiency (POI).: In this report, menopausal symptoms related to anti-cancer treatment are described. Menstrual disturbances associated with the use of adjuvant chemotherapy, endocrine therapy, and targeted therapy against human epidermal growth factor receptor 2 (HER2) in premenopausal women withBC are discussed. To prevent menopausal symptoms, CRA and POI, data on the efficacy of temporary ovarian suppression with gonadotropin-releasing hormone analogues (GnRHa) during chemotherapy are highlighted. Pooled analyses have confirmed that concurrent administration of GnRHa during chemotherapy could significantly reduce the risk of developing chemotherapy-induced POI in premenopausal women with early-stageBC. In addition, reports have suggested that embryo/oocyte cryopreservation may increase the chance of pregnancy after the diagnosis ofBC, although such data remain limited.: Commonly experienced by pre-menopausal women withBC, anti-cancer treatment could cause severe menopausal symptoms. Temporary ovarian suppression with GnRHa during chemotherapy provided asafe and efficient strategy to reduce the likelihood of chemotherapy-induced POI in premenopausal patients with early-stageBC undergoing (neo)-adjuvant chemotherapy.
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| http://dx.doi.org/10.1080/14740338.2021.1926980 | DOI Listing |
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