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The CD4/CD8 ratio is associated with T lymphocyte functions in long-term virally suppressed patients with HIV.
BMC Infect Dis
January 2025
Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Objective: Long-term management of people living with HIV (PLWHs) often relies on CD4 T cell counts for assessing immune recovery, yet a single metric offers limited information. This study aimed to explore the association between the CD4/CD8 ratio and T lymphocyte activities in PLWHs.
Methods: 125 PLWHs and 31 HIV-uninfected controls (UCs) were enrolled and categorized into four groups based on their CD4/CD8 ratios: extremely low ratio (ELR) group: 0.
The impact of specialist cardiology inpatient care on the long-term outcomes of non-ST-segment elevation myocardial infarction (NSTEMI): A nationwide cohort study.
Int J Cardiol
January 2025
Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, UK; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, UK. Electronic address:
Background: Specialist cardiac care has been shown to reduce inpatient mortality following non-ST segment myocardial infarction (NSTEMI), but whether this benefit extends beyond index admission is unclear.
Methods: Using the linked Myocardial Ischaemia National Audit Project (MINAP) registry, and Office for National Statistics mortality recording, we included 425,205 NSTEMI patients admitted to UK hospitals, between January 2005 and March 2019 that survived to discharge. 217,964 (52 %) were admitted to a specialty cardiac ward.
Volcanic aerosols captured by plants: A study of nanoparticles and their chemical composition.
Sci Total Environ
January 2025
Université Paris Cité - Institut de Physique du globe de Paris, CNRS, F75005 Paris, France.
Nanoparticles (NPs) exhibit high reactivity and mobility in the environment, and a significant capacity to penetrate living organisms, potentially leading to harmful effects. Volcanoes are the second major source of natural NPs emitted into the atmosphere, with an estimated flux of 342 Tg/year. Few studies have focused on their fate.
View Article and Find Full Text PDFA lot of noise about nothing? Speech-to-noise ratios rather than noise predict language outcomes in preschoolers.
J Exp Child Psychol
January 2025
Callier Center for Communication Disorders, University of Texas at Dallas, Richardson, TX 75080, USA; Center for Children and Families, University of Texas at Dallas, Richardson, TX 75080, USA.
It has been proposed that a childhood in a noisy household might lead to poor language skills and slow development of language areas of the brain. Notably, a direct link between noisy households and language development has not been confirmed. Households might have high levels of noise for a range of reasons, including situational (near a large road intersection or airport), family (large families), and cultural (differences in beliefs surrounding noise in the home, including media use).
View Article and Find Full Text PDFStudy protocol for a multi-center stepped-wedge cluster randomized trial to explore the usability and outcomes among young people living with HIV in Kiambu and Kirinyaga counties of Kenya, using an online health portal.
PLOS Digit Health
January 2025
Johnson & Johnson Global Public Health, Janssen Pharmaceutica NV, Beerse, Belgium.
While the incidence of Human Immunodeficiency Virus (HIV) infection is decreasing in most age groups worldwide, it is rising among adolescents and young adults, who also face a higher rate of HIV-related deaths. This tech-savvy demographic may benefit from an online patient portal designed to enhance patient activation-empowering them to manage their health independently. However, the effectiveness of such digital health interventions on young HIV patients in Kenya remains uncertain.
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