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Increasing hemoglobin concentration with an artificial oxygen carrier improves severe anemia-induced degraded cognitive function. | LitMetric

Increasing hemoglobin concentration with an artificial oxygen carrier improves severe anemia-induced degraded cognitive function.

J Trauma Acute Care Surg

From the Department of Anesthesia and Perioperative Care, University of California (R.B.W.), San Francisco, California; Department of Pathology (R.D.), University of Michigan Medical School; US Army Institute of Surgical Research (A.P.C.), JBSA-Ft Sam Houston, San Antonio, Texas; Department of Medicine (A.P.C.), Uniformed Services University of the Health Sciences, Bethesda, Maryland; Pulmonary and Critical Care Medicine (V.R.), Wellstar Health System, Marietta, Georgia; Department of Anesthesiology and Perioperative Medicine and Bioengineering (J.H.W.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Laboratory Medicine Program (C.C.-G.) and Department of Medical Oncology and Hematology (C.C.-G.), University Health Network, University of Toronto, Toronto, Ontario, Canada.

Published: August 2021

AI Article Synopsis

Article Abstract

Before death, patients commonly experience impaired consciousness for a significant period, frequently preventing family and others from final interactions with the patient. Some of these episodes of cognitive impairment may be treatable, with treatment not offered owing to the perception of ultimate futility or expense, or both. One of the causes of terminal loss of consciousness or decreased lucidity can be inadequate cerebral oxygen delivery. We report five cases from four institutions where an infusion of a hemoglobin-based oxygen carrier to patients who were unconscious or not lucid owing to acute severe anemia (hemoglobin range, 2.1-5.2 g/dL) resulted in awakening or lucidity. We review briefly human cognitive function and anemia and remark about the use of a hemoglobin-based oxygen carrier for acute severe anemia when red cell transfusion is not an option.

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Source
http://dx.doi.org/10.1097/TA.0000000000003261DOI Listing

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