AI Article Synopsis
- Enhanced electrochemiluminescence (ECL) signals were observed in CdS quantum dots capped with 3-mercaptopropionic acid after activating carboxyl groups with EDC, allowing signals strong enough to be photographed with a mobile phone.
- A sandwich immunosensor for detecting the Zika virus was created using silica microspheres and MPA@CdS QDs as ECL labels, benefiting from dual amplification methods.
- The immunosensor demonstrated a linear detection range from 1.0 fg mL-1 to 1.0 ng mL-1, with an impressive detection limit of 0.3 fg mL-1.
Article Abstract
Enhanced electrochemiluminescence (ECL) signals of CdS quantum dots capped with 3-mercaptopropionic acid (MPA@CdS QDs) have been observed after using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (EDC) to activate the carboxyl groups. The generated ECL signals are strong enough that their images can be captured using a Huawei mobile phone. A possible mechanism for the generation of enhanced ECL signals has been proposed. Then, a sandwich immunosensor platform for detecting Zika virus (ZIKV) was fabricated with silica microspheres as the carrier and MPA@CdS QDs as ECL signal labels. Due to the dual signal amplification of EDC activation and microsphere enrichment, good linearity from 1.0 fg mL-1 to 1.0 ng mL-1 was exhibited by the QD-based ECL immunosensor for ZIKV detection. The detection limit was 0.3 fg mL-1.
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| http://dx.doi.org/10.1039/d0an02437f | DOI Listing |
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