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F-NaF uptake on vascular PET imaging in symptomatic versus asymptomatic atherosclerotic disease: A meta-analysis.
Vasc Med
October 2024
Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Introduction: F-sodium fluoride (NaF) positron-emission tomography (PET) is increasingly being used to measure microcalcification in atherosclerotic disease in vivo. Correlations have been drawn between sodium fluoride uptake and the presence of high-risk plaque features, as well as its association with clinical atherosclerotic sequelae. The aim of this study was to perform a meta-analysis of NaF uptake on PET imaging and its relation to symptomatic and asymptomatic disease.
View Article and Find Full Text PDFAortic Uptake of F-NaF and F-FDG and Calcification Predict the Development of Abdominal Aortic Aneurysms and Is Attenuated by Drug Therapy.
Arterioscler Thromb Vasc Biol
September 2024
Department of Radiology, Keio University School of Medicine, Tokyo, Japan (T.N., R.M., Y.I., K.T., M.J.).
Article Synopsis
- The study investigates whether the uptake of F-FDG and F-NaF can predict the expansion of abdominal aortic aneurysms in a rat model, highlighting a correlation between imaging uptake and pathological markers.
- The research involved 74 male rats and monitored changes in aortic size and imaging metrics over a period of 8 weeks, with effects from different medications assessed.
- Results indicated that F-FDG and F-NaF uptake varied over time, with specific drugs influencing these changes, and showed that F-NaF uptake at 1 week was the strongest predictor of final aortic size, suggesting potential for these imaging techniques in monitoring aneurysm progression.
Sex differences in coronary atherosclerotic plaque activity using F-sodium fluoride positron emission tomography.
Eur J Nucl Med Mol Imaging
November 2024
Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
Introduction: There are sex differences in the extent, severity, and outcomes of coronary artery disease. We aimed to assess the influence of sex on coronary atherosclerotic plaque activity measured using coronary F-sodium fluoride (F-NaF) positron emission tomography (PET), and to determine whether F-NaF PET has prognostic value in both women and men.
Methods: In a post-hoc analysis of observational cohort studies of patients with coronary atherosclerosis who had undergone F-NaF PET CT angiography, we compared the coronary microcalcification activity (CMA) in women and men.
Rosuvastatin effect on atherosclerotic plaque metabolism: A subclinical atherosclerosis imaging study with F-NaF PET-CT.
Atherosclerosis
August 2024
Cardiology Department, Unidade Local de Saúde de Coimbra, Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075, Coimbra, Portugal; Institute of Nuclear Sciences Applied to Health - University of Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Rua Larga, 3004-504, Coimbra, Portugal; Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Background And Aims: Atherosclerotic plaque fluorine-18 sodium fluoride (F-NaF) uptake on positron emission tomography with computed tomography (PET-CT) identifies active microcalcification and has been shown to correlate with clinical instability in patients with cardiovascular (CV) disease. Statin therapy promotes coronary macrocalcification over time. Our aim was to investigate rosuvastatin effect on atheroma F-NaF uptake.
View Article and Find Full Text PDFHigh Tyrosol and Hydroxytyrosol Intake Reduces Arterial Inflammation and Atherosclerotic Lesion Microcalcification in Healthy Older Populations.
Antioxidants (Basel)
January 2024
Geriatrics Unit, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 4N4, Canada.
Aging is an important risk factor for cardiovascular diseases and convincing data have shown that chronic low-grade inflammation, which develops with advanced age, contributes significantly to cardiovascular risk. The present study aimed to use F-FDG/F-NaF-PET/CT imaging to, respectively, gauge arterial inflammation and microcalcification in a healthy elderly population and to assess the potential benefits of a tyrosol- and hydroxytyrosol-rich diet on these two markers of atherosclerotic plaque fragility. Eleven healthy participants (mean age 75 ± 5.
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