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Frontline treatment of follicular lymphoma: What will it take to change current practice?
Blood
January 2025
The Christie NHS Foundation Trust, United Kingdom.
Follicular lymphoma is the most common subtype of indolent lymphoma. Despite multiple trials over the past decade showing improved progression-free survival with new first-line therapeutic strategies -such as anti-CD20 maintenance therapy and new glycoengineered anti-CD20 antibodies- no standardized approach has been widely adopted in routine clinical practice. Several factors may explain this, including the increased incidence of infectious adverse events associated with these therapies, particularly during the COVID-19 pandemic, and the lack of overall survival benefit despite long-term follow-up.
View Article and Find Full Text PDFThe "magic" of looking at that score: A multilevel investigation of therapist review of client symptom measures and client clinical outcome.
J Couns Psychol
January 2025
Marriage and Family Therapy Program, Sentio University.
Randomized controlled trials have shown that using client feedback obtained from routine outcome monitoring can lead to better clinical outcomes in psychotherapy. However, existing randomized controlled trial studies did not address the between-person and within-person effects of routine outcome monitoring simultaneously. To fill this critical gap, this study conducted a multilevel analysis to explore the effect of therapist utilization of client symptom outcome data in a naturalistic practice setting.
View Article and Find Full Text PDFDepression in adolescence and the understanding of health-A phenomenographic study.
PLoS One
January 2025
Department of Health and Care, School of Health and Welfare, Halmstad University, Halmstad, Sweden.
Health is multifaceted, with divergent interpretations in diverse cultures and groups of individuals. The ways individuals understand health might aid in developing future interventions. There is scant knowledge on how adolescents with depression conceptualise health.
View Article and Find Full Text PDFTransient shear wave elastometry using a portable magnetic resonance sensor.
Magn Reson Med
January 2025
MRI Research Centre, Physics, University of New Brunswick, Fredericton, New Brunswick, Canada.
Purpose: Magnetic resonance elastography (MRE) provides detailed maps of tissue stiffness, helping to diagnose various health conditions, but requires the use of expensive clinical MRI scanners. Our approach utilizes compact, cost-effective portable MR sensors that offer bulk characterization of material properties in a region of interest close to the surface (within 1-2 cm). This accessible instrument could enable routine monitoring and prevention of diseases not readily evaluated with conventional tools.
View Article and Find Full Text PDFNegative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial.
JAMA
January 2025
Worcestershire Royal Hospital, Worcester, United Kingdom.
Importance: Patients undergoing unplanned abdominal surgical procedures are at increased risk of surgical site infection (SSI). It is not known if incisional negative pressure wound therapy (iNPWT) can reduce SSI rates in this setting.
Objective: To evaluate the effectiveness of iNPWT in reducing the rate of SSI in adults undergoing emergency laparotomy with primary skin closure.
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