AI Article Synopsis
- This study investigates the link between sarcopenia (loss of muscle mass) and orthostatic hypotension (a drop in blood pressure when standing) in elderly individuals, as both can increase the risk of falls.
- Out of 91 elderly patients assessed, 31.9% were found to have sarcopenia; those with sarcopenia exhibited more frequent orthostatic hypotension and other related symptoms compared to non-sarcopenic patients.
- The findings suggest that age-related sarcopenia heightens the risk of orthostatic hypotension in older adults, potentially explaining a higher occurrence of falls among these individuals.
Article Abstract
Objectives: This study aims to determine the association of sarcopenia with orthostatic hypotension (OH) which is a significant precursor to falls and related injuries in elderly patients.
Patients And Methods: A total of 91 outpatients (18 males, 73 females; mean age 79.3±4.0 years; range, 75 to 91 years) were prospectively enrolled and those who were eligible underwent comprehensive sarcopenia assessment including measurement of muscle mass, strength, physical performance, anthropometric measurements along with frailty tests. Patients classified as sarcopenic or non-sarcopenic based on these measurements underwent supine and standing blood pressure (BP) measurements. The frequency of OH was compared between the two groups.
Results: Of the 91 patients, 29 (31.9%) had sarcopenia. There was no statistical difference in measurements of functional tests which consisted of gait speed, timed up-and-go test and handgrip strength. However, timed sit-to-stand test values were higher in sarcopenic patients (18.2±7.9 vs. 15.0±5.1, p=0.04). Patients with sarcopenia developed OA and intolerance more often compared to the non-sarcopenic patients (n=15 [50.0%] vs. n=14 [23.0%], p<0.01 and n=13 [44.8%] vs. n=9 [15.3%], p<0.01, respectively). The adjusted odds ratio for sarcopenia was 7.80 (95% confidence interval 1.77-34.45), p=0.007.
Conclusion: Age-related sarcopenia increases the risk of OA in the elderly. This may in part explain the increased incidence of falls and also help identification of risky elderly patients for orthostatic BP drops.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088799 | PMC |
| http://dx.doi.org/10.5606/tftrd.2021.5461 | DOI Listing |
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