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SIK2 orchestrates actin-dependent host response upon infection. | LitMetric

AI Article Synopsis

Article Abstract

is an intracellular pathogen of a substantial global health concern. In order to identify key players involved in infection, we performed a global host phosphoproteome analysis subsequent to bacterial infection. Thereby, we identified the kinase SIK2 as a central component of the host defense machinery upon infection. SIK2 depletion favors the escape of bacteria from the -containing vacuole (SCV) and impairs Xenophagy, resulting in a hyperproliferative phenotype. Mechanistically, SIK2 associates with actin filaments under basal conditions; however, during bacterial infection, SIK2 is recruited to the SCV together with the elements of the actin polymerization machinery (Arp2/3 complex and Formins). Notably, SIK2 depletion results in a severe pathological cellular actin nucleation and polymerization defect upon infection. We propose that SIK2 controls the formation of a protective SCV actin shield shortly after invasion and orchestrates the actin cytoskeleton architecture in its entirety to control an acute infection after bacterial invasion.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126862PMC
http://dx.doi.org/10.1073/pnas.2024144118DOI Listing

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