The species is known as a psychrophilic pathogenic fungus which is ubiquitously distributed in Antarctica. While the studies of its secondary metabolites are infrequent. Systematic research of the metabolites of the Antarctic fungus sp. HSX2#-11 led to the isolation of one new pyridine derivative, 4-(2-methoxycarbonyl-ethyl)-pyridine-2-carboxylic acid methyl ester (), together with one pyrimidine, thymine (), and eight diketopiperazines, -(dehydroAla-l-Val) (), -(dehydroAla-l-Ile) (), -(dehydroAla-l-Leu) (), -(dehydroAla-l-Phe) (), -(l-Val-l-Phe) (), -(l-Leu-l-Phe) (), -(l-Trp-l-Ile) () and -(l-Trp-l-Phe) (). The structures of these compounds were established by extensive spectroscopic investigation, as well as by detailed comparison with literature data. This is the first report to discover pyridine, pyrimidine and diketopiperazines from the genus of .
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