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The regulation of miRNAs using curcumin and other polyphenols during the prevention and treatment of Alzheimer's disease.
Hum Mol Genet
November 2024
Medical College, Xi'an Peihua University, Xi'an, Shaanxi 710125, China.
Alzheimer's disease (AD), a prevalent neurodegenerative disorder, predominantly affects individuals over the age of 65 and poses significant challenges in terms of effective management and treatment. The disease's pathogenesis involves complex molecular pathways including misfolded proteins accumulation, neuroinflammation, and synaptic dysfunction. Recent insights have highlighted the role of microRNAs (miRNAs) as critical regulators within these pathways, where they influence gene expression and contribute to the pathophysiological landscape of AD.
View Article and Find Full Text PDFEffect of curcumin on physico-mechanical properties of heat polymerized denture base resin.
BMC Oral Health
October 2024
Department of Prosthodontics, Sri Ramaswamy Memorial Dental College, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu, India.
Purpose: Current denture base resins lack adequate strength and antimicrobial properties, necessitating the exploration of alternative solutions. The purpose of this study was to evaluate the effects of curcumin incorporation on the physico-mechanical properties of heat-cured denture base resin, filling a gap in the literature regarding this correlation.
Methods: Heat-cured denture base resin was supplemented with increasing concentrations of curcumin (CR).
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