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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115998 | PMC |
| http://dx.doi.org/10.1097/CM9.0000000000001379 | DOI Listing |
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Anal Biochem
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Rehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan, China. Electronic address:
Background: Multiple sclerosis (MS) is an autoimmune inflammatory disorder that causes neurological disability. Dysregulated lipid metabolism contributes to the pathogenesis of MS. This study aimed to identify lipid metabolism-related gene markers and construct a diagnostic model for MS.
View Article and Find Full Text PDFhsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p.
Sci Rep
January 2025
Department of Oncology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1, Minde Road, Nanchang, 330000, Jiangxi Province, P.R. China.
Circular RNAs (circRNAs) are widely involved in diverse biological processes of cancers. Nonetheless, the potential function of hsa_circ_0008305 in hepatocellular carcinoma (HCC) remains largely unknown. This study aims to elucidate the role and underlying mechanism of hsa_circ_0008305 in HCC.
View Article and Find Full Text PDFTranscriptome analysis reveals the genetic basis underlying the formation and seasonal changes of nuptial pads in Rana chensinensis.
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December 2024
Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, 152 Luoyulu, Hongshan District, Wuhan, 430079, China.
Background: Nuptial pads, a typical sexually dimorphic trait in anurans, are located on the first digit of the male forelimb in Rana chensinensis and exhibit morphological changes synchronized with breeding cycles. However, the genetic mechanisms underlying its formation and seasonal changes remain poorly understood.
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Currently, the molecular mechanisms underlying bladder cancer progression remain unclear. Immune checkpoint inhibitors (ICIs) have been used to treat bladder cancer, but their efficacy is limited. Exosomes, which play a critical role in cell communication, can alter the tumor microenvironment.
View Article and Find Full Text PDFAKR1C3 mediates gastric cancer cell invasion and metastasis via the AKT and JNK/p-NF-κB signaling pathways.
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Department of Gastroenterology and Fujian Institute of Digestive Disease, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, Fujian, China.
Article Synopsis
- * The study highlights the downregulation of AKR1C3 in GC tissues, which is associated with a more aggressive cancer phenotype and poorer patient prognosis.
- * AKR1C3 shows potential as a tumor suppressor by inhibiting cell invasion and metastasis through interference with the p-JNK pathway, suggesting its value as a diagnostic and prognostic marker for gastric cancer treatment.
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