methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes.

To investigate  methylation in the brains of bipolar disorder (BD) patients and its association with mRNA levels and comethylation with myelin genes. Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. 5-methylcytosine levels were increased and directly associated with b mRNA expression in the brains of BD patients. We also observed that was comethylated with a group of myelin genes. is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, comethylation with myelin genes supports the role of this receptor in myelination.