Atomic force microscopy can observe structures of liquids (solvents) on solid surfaces as oscillating force curves. The oscillation originates from the solvation force, which is affected by the interaction between the probe, substrate, and solvents. To investigate the effects of the interactions on the force curve, we calculated the force curves by integral equation theory with various probe and substrate conditions. The probe solvophilicity affected the force curves more than the substrate solvophilicity in our calculation, and its reason is qualitatively explained by the amount of the desolvated solvents. We evaluated the probes and parameters in terms of the qualitative estimation of the number density distribution of the solvent on the wall. The negative of the force curve's derivative with respect to the surface separation reflected the number density distribution better than the force curve. This parameter is based on the method that is proposed previously by Amano et al. [Phys. Chem. Chem. Phys. 18, 15534 (2016)]. The normalized frequency shift can also be used for the qualitative estimation of the number density distribution if the cantilever amplitude is small. Solvophobic probes reflected the number density distribution better than the solvophilic probes. Solvophilic probes resulted in larger oscillation amplitudes than solvophobic probes and are suitable for measurements with a high S/N ratio.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1063/5.0046600 | DOI Listing |
N Engl J Med
January 2025
From the Department of Medicine, University of Auckland, Auckland, New Zealand (M.J.B., Z.N., A.M., C.G., V.P., B.M., A.G., I.R.R., G.G., A.H.); the Department of Psychology, Stanford University, Stanford, CA (C.G.); and the Department of Radiology, Starship Hospital, Auckland, New Zealand (S.B.).
Background: Zoledronate prevents fractures in older women when administered every 12 to 18 months, but its effects on bone density and bone turnover persist beyond 5 years. Whether infrequent zoledronate administration would prevent vertebral fractures in early postmenopausal women is unknown.
Methods: We conducted a 10-year, prospective, double-blind, randomized, placebo-controlled trial involving early postmenopausal women (50 to 60 years of age) with bone mineral density T scores lower than 0 and higher than -2.
J Appl Physiol (1985)
January 2025
Department of Electrical Engineering and Automation, Aalto University, Espoo, Finland.
Disruption of the blood supply to a limb in conjunction with active movement boosts muscle growth, aids in rehabilitation, and allows controlled exploration of the sensorimotor system. Yet, the underlying neuromechanical changes have not been observed in great detail. This study aims to report the acute neuromuscular effects of temporary blood flow restriction (BFR) through behavioral changes at the level of motor units (MUs) using high-density surface electromyography on the abductor digiti minimi muscle during 20 trapezoidal and sinusoidal isometric force tracking tasks (5 pre-BFR, 5 during BFR, and 10 post-BFR).
View Article and Find Full Text PDFActa Neurol Belg
January 2025
Department of Neurology, CHU Nîmes, Hôpital Carémeau, Univ. Montpellier, Rue du Pr Debré, Nîmes, 30900, France.
Introduction: Radiological calcified cerebral embolism (CCE) characteristics have been reported in small case series. Our aim was to describe clinical and radiological CCE characteristics in a large number of CCE and to compare characteristics between different patient groups.
Methods: Characteristics of 79 stroke patients with CCE were analyzed retrospectively.
Mol Neurobiol
January 2025
Department of Physiology, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.
This study aimed to investigate the impact of early childhood chronic stress on the development of the brain extracellular matrix (ECM) and how alterations in the ECM following early-life adversity (ELA) affect auditory learning and cognitive flexibility. ELA was induced through a combination of maternal separation and neonatal isolation in male Sprague-Dawley rats, and the success of the ELA model was assessed behaviorally and biochemically. A cortex-dependent go/no-go task with two phases was used to determine the impact of ELA on auditory learning and cognitive flexibility.
View Article and Find Full Text PDFMetab Brain Dis
January 2025
School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700 032, India.
Alzheimer's disease is a complex neurodegenerative disease characterized by progressive decline in cognitive function and behaviour. Ginger is the rhizome of the plant Zingiber officinale Roscoe, has been an important ingredient of many Ayurveda formulations to treat neurological disorders. The present study aims to estimate the variation of 6-gingerol content in nine different ginger samples collected from Manipur, India, investigate the neuroprotective potential of the most potent ginger sample against scopolamine-induced cognitively impaired mice, and validate the therapeutic claim by molecular docking analysis.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!