AI Article Synopsis
- Glioblastoma is a highly aggressive and common brain tumor in adults, with patients facing a poor prognosis, especially after surgery due to potential infections.
- Research revealed a case of longer-than-expected survival in a glioblastoma patient who developed multiple post-surgery infections, highlighting the uncertain impact of these infections on patient outcomes.
- A review of four studies with a total of 29 glioblastoma patients showed that Staphylococcus bacteria were common culprits in postoperative infections, and while median survival was generally low, one study suggested higher survival rates in infected patients, suggesting a possible link that requires further investigation.
Article Abstract
Introduction: Glioblastoma is the most common primary brain tumor in adults with the worst overall survival. Post-craniotomy intracranial infections are not infrequent after surgery; however, their impact on overall survival of glioblastoma patients remains unclear. Here we report the case of an unusual longer survival of a glioblastoma patient affected by multiple infections and the review of the literature on this topic.
Evidence Acquisition: PubMed, Embase and Cochrane search engines were reviewed for papers describing outcome of patients suffering from glioblastoma and associated cerebral infections.
Evidence Synthesis: Four papers accounting a total of 29 patients met the eligibility criteria. Staphylococcus aureus and Staphylococcus epidermidis resulted the most common bacteria causing post-craniotomy intracranial infections in brain tumor patients. The overall median survival rate was 18±18.12 months when adding all 29 patients. Only one study described a significant higher survival rate for the infected group.
Conclusions: Glioblastoma is the most frequent malignant brain tumor with a very poor outcome/survival. In the literature few cases described an exceptional longer survival often associated with a postoperative infection. To date, the pathophysiology behind this longer survival remains unclear, but it seems that Staphylococcus species could have an influence on the progression of this aggressive brain tumor.
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| http://dx.doi.org/10.23736/S0390-5616.21.05277-2 | DOI Listing |
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