Seven previously undescribed sesterterpenes were characterized from Penicillium roqueforti YJ-14 by solid fermentation. Their structures were initially investigated in detail by spectroscopic analyses and HR-ESI-MS and were further confirmed by X-crystallography. In in vitro bioassays, compounds 1, 5 and 7 showed cytotoxic activity against the MCF-7 breast cancer cell line with IC values of 7.98 ± 0.93, 6.42 ± 0.41 and 7.32 ± 0.18 μM, respectively. Compounds 5 and 7 displayed significant cytotoxicity against the A549 lung cancer cell line (IC values of 4.83 ± 0.22 μM and 4.58 ± 0.85 μM, respectively). In addition, compound 5 showed an obvious inhibitory effect on nitric oxide production in LPS-activated RAW264.7 macrophages with an IC value of 9.53 ± 0.16 μM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.phytochem.2021.112762 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Use of dielectric-barrier discharge (DBD) cold plasma for control of bread spoilage fungi.
Int J Food Microbiol
December 2024
Department of Food Engineering and Technology, School of Food Engineering, Universidade Estadual de Campinas, São Paulo, Brazil. Electronic address:
Bread is a greatly consumed bakery product worldwide. Unfortunately, it is an optimal substrate for fungal contamination and deterioration (aw > 0.95), commonly caused by the genera Penicillium, Paecilomyces, and Aspergillus, resulting in significant economic losses.
View Article and Find Full Text PDFInvestigation on L-rhamnose metabolism of subsp. DSM 20001 and its propionate-containing fermentates.
Appl Environ Microbiol
December 2024
Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.
Propionate is an important short-chain carboxylic acid (SCCA) that serves as an effective antimicrobial agent for food preservation. Previous research has highlighted that few can synthesize propionate by metabolizing deoxyhexoses via the fermentation intermediate 1,2-propanediol (1,2-PD). In this study, we investigated propionate production by subsp.
View Article and Find Full Text PDFDifferent metabolite profiles across Penicillium roqueforti populations associated with ecological niche specialisation and domestication.
IMA Fungus
November 2024
Laboratoire Universitaire de Biodiversité Et Ecologie Microbienne, Univ. Brest, INRAE, 29280, Plouzane, France.
Fungi are known to produce many chemically diversified metabolites, yet their ecological roles are not always fully understood. The blue cheese fungus Penicillium roqueforti thrives in different ecological niches and is known to produce a wide range of metabolites, including mycotoxins. Three P.
View Article and Find Full Text PDFSustainable detergent-disinfectant agent based on whey mineralizate and silver nanoparticles for cleaner production in dairy industry.
Sci Rep
October 2024
Department of Biology, Faculty of Education, Albaydha University, Al-Baydha, Yemen.
Detergents and disinfectants for dairy industry must meet a variety of characteristics, including low toxicity, high antibacterial activity, and excellent rinsing of pollutants from working surfaces. This work presents an innovative detergent-disinfectant agent based on whey mineralizate and silver nanoparticles (Ag NPs), which allows reducing production costs and ensuring high cleanliness of treated surfaces compared to analogues. For this purpose, a method for obtaining sols of Ag NPs stabilized with didecyldimethylammonium bromide (Ag NPs-DDAB) was developed and optimized using neural network algorithms.
View Article and Find Full Text PDFAccumulated melanin in molds provides wavelength-dependent UV tolerance.
Photochem Photobiol Sci
September 2024
Department of Microbial Control, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, Tokushima, Japan.
Article Synopsis
- Fungal contamination is a significant risk to public health and food safety, with molds capable of thriving under stress due to melanin production.
- The study explored how melanin affects UV sensitivity, finding that mature spores are less sensitive to UV light, while reducing melanin through inhibitors increased sensitivity.
- The research determined that the most effective UV wavelength for inhibiting fungi is around 270 nm, suggesting that melanin provides greater protection against UV damage, which can inform future systems for purifying air and water by targeting molds.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!