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The use of perioperative cephalosporin prophylaxis in patients who have a pre-existing penicillin allergy.
Surgery
January 2025
Department of Internal Medicine, Tampere University Hospital, Wellbeing Services County of Pirkanmaa and Faculty of Medicine and Health Technology, Tampere, Finland; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Background: Studies have shown an association between a reported penicillin allergy and an increased risk of surgical site infection. The risk is due to avoidance of cephalosporins and to the use of alternative classes of antibiotics in surgical prophylaxis. The aim of this study was to examine the safety of using cephalosporins in patients with a penicillin allergy label.
View Article and Find Full Text PDFDetermining the role of basophil activation testing in reported type 1 allergy to beta-lactam antibiotics.
Front Allergy
December 2024
Department of Dermatology, Eberhard Karls University, Tuebingen, Germany.
Background: Allergy to beta-lactam antibiotics (BLA), especially to penicillin, is the most commonly reported drug allergy by patients. Alternative antibiotics can yield negative consequences, such as extended hospitalization days due to less efficacy and overall higher costs. The basophil activation test (BAT) is an assay, in which activation of an individual's own basophils is quantified by flow cytometry.
View Article and Find Full Text PDFA Guide to Pediatric Antibiotic Allergy Testing: A Report from the United States Drug Allergy Registry.
J Allergy Clin Immunol Pract
January 2025
Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Pediatric antibiotic labels are common, and unnecessary antibiotic avoidance is associated with negative personal and public health outcomes; as a result, there is an increasing emphasis on the importance of pediatric antibiotic allergy evaluations. Different testing strategies have been advised, including skin testing and challenge testing with varied doses and duration. Established consensus testing protocols are lacking.
View Article and Find Full Text PDFChlorine Dioxide Dry Gas: A Promising Solution for Effective Decontamination of Cephalosporin Compounds.
Appl Biosaf
December 2024
Royal Society of Biology, London, United Kingdom.
Introduction: Cephalosporins can trigger hypersensitivity reactions in certain individuals. Consequently, strict regulations restrict the production of non-beta-lactam substances during or after cephalosporin manufacturing. Dry chlorine dioxide gas (dClO), together with ultra-performance liquid chromatography Mass spectrometry/mass spectrometry (UPLC-MS/MS) detection methods, has emerged as a promising method for decontaminating cephalosporin compounds.
View Article and Find Full Text PDFDurlobactam in combination with β-lactams to combat .
Antimicrob Agents Chemother
December 2024
Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
() presents significant clinical challenges. This study evaluated the synergistic effects of a β-lactam and β-lactamase inhibitor combination against and explored the underlying mechanisms. Synergy was assessed through MIC tests and time-kill studies, and binding affinities of nine β-lactams and BLIs to eight target receptors (L,D-transpeptidases [LDT] 1-5, D,D-carboxypeptidase, penicillin-binding protein [PBP] B, and PBP-lipo) were assessed using mass spectrometry and kinetic studies.
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