Although generic drugs are typically inexpensive, rising prices among some generic drugs in recent years have raised concern. Using Medicaid data, we found that one in five generic drugs sold in the US experienced a price spike (defined as a doubling in price over the course of one year) initiated by at least one manufacturer during the period 2014-17. There was a trend toward fewer price spikes each year, from 7.8 percent of drugs in 2014 to 5.8 percent in 2017. Among drugs experiencing price spikes, 51 percent were injected products, 64 percent had three or fewer manufacturers, and 18 percent were in shortage at the time of the spike. Generic drug price spikes cost Medicaid $1.5 billion during 2014-16, representing 4.2 percent of all Medicaid generic drug spending in that period. The trend toward fewer price spikes over time may be due to increased public scrutiny and regulatory actions. However, price spikes can be very costly, and additional policies are needed to both ensure adequate competition and control prices among generic drugs.
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http://dx.doi.org/10.1377/hlthaff.2020.02020 | DOI Listing |
Sci Total Environ
March 2025
Center for Systems Integration and Sustainability, Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI 48823, USA. Electronic address:
This study investigates the cumulative and interactive impacts of drought and COVID-19 on soybean production in Brazil, focusing on cascading economic and operational disruptions. The country has faced numerous drought events in recent years (1989 to 2022), culminating with one in 2022 that, together with the occurrence of COVID-19, led to the highest decline in soybean production since 1990 (10.5 % of the total national production).
View Article and Find Full Text PDFEPJ Data Sci
February 2025
Oxford-Man Institute of Quantitative Finance, University of Oxford, Walton Street, Oxford, UK.
Understanding stock market instability is a key question in financial management as practitioners seek to forecast breakdowns in long-run asset co-movement patterns which expose portfolios to rapid and devastating collapses in value. These disruptions are linked to changes in the structure of market wide stock correlations which increase the risk of high volatility shocks. The structure of these co-movements can be described as a network where companies are represented by nodes while edges capture correlations between their price movements.
View Article and Find Full Text PDFGerontologist
February 2025
Carl H. Lindner College of Business, University of Cincinnati, Cincinnati, OH, USA.
Background And Objectives: Just as the U.S. population is aging and racially diversifying, housing prices are spiking.
View Article and Find Full Text PDFEpilepsy Res
February 2025
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
Objective: This study aimed to assess the long-term outcome and prognostic factors of vagus nerve stimulation (VNS) for drug-resistant epilepsy (DRE) using real-world data.
Method: We included 189 DRE patients who underwent VNS implantation between 2005 and 2018 at nine national hospitals in Korea. Seizure-frequency data obtained quarterly one year before and after surgery and annually up to four years after surgery were collected from medical records.
JCI Insight
January 2025
University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France.
CD8+ T cells are critical for immune protection against severe COVID-19 during acute infection with SARS-CoV-2. However, the induction of antiviral CD8+ T cell responses varies substantially among infected people, and a better understanding of the mechanisms that underlie such immune heterogeneity is required for pandemic preparedness and risk stratification. In this study, we analyzed SARS-CoV-2-specific CD4+ and CD8+ T cell responses in relation to age, clinical status, and inflammation among patients infected primarily during the initial wave of the pandemic in France or Japan.
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